Biography

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Vasily graduated from Moscow State University in 1993 with an MSc in physics. He undertook his PhD in biophysics at the Molecular Biology Institute in Moscow working on the theoretical analysis of spectroscopic properties of high-spin ferrous haem proteins. In 1997 he joined UEA as a postdoctoral researcher working with Prof AJ Thomson, FRS on the development and application of novel theoretical and computational methods for analysing electronic, magnetic and optical properties of transition metal centres in proteins, single molecular magnets (nanomagnets) and systems containing spin radicals. In 2004 Vasily was awarded an Advanced EPSRC Fellowship. He was awarded the Inorganic Biochemistry Discussion Group (IBDG) of the RSC Inaugural Young Investigators Award in 2006 for “for development of theory, analysis and computational methods for advanced spectroscopies with application to metal centres in proteins”. In 2007 Vasily was appointed as a Lecturer in Computational Chemistry and was promoted to Senior lecturer in 2012.

In 2008 he was a Visiting Scholar at the Centre for Magnetic Resonance, the University of Queensland, Australia and in 2009 he was a Visiting Fellow at the National Institute for Advanced Industrial Science and Technology, Tsukuba, Japan.

Vasily’s research interests broadly concern with the areas of chemistry and molecular biophysics which require the application of the methods of physical, theoretical and computational chemistry for analysing data from advanced spectroscopic techniques applied to molecular systems. These include Electron Paramagnetic Resonance (EPR), Magnetic Circular Dichroism (MCD), Nuclear Inelastic Scattering (NIS) and muon spectroscopy.

Vasily's current research focuses on Molecular Dynamics (MD) simulations on complex molecular systems with introduced spin labels and probes and advancing  theoretical/computational approaches for prediction of motional EPR spectra from MD results. This includes proteins and soft matter systems such as liquid crystals and phospholipids assemblies.  Vasily’s group combines modelling work with experimental EPR.

 

Selected publications

Gopee H., Cammidge A.N., and Oganesyan V.S.
Probing Columnar Discotic Liquid Crystals by EPR Spectroscopy with a Rigid-Core Nitroxide Spin Probe
Angew. Chem. Int. Ed., 52, 34, 8917, 2013
DOI: 10.1002/anie.201303194

Chami, F., Wilson, M.R. and Oganesyan, V.S
Molecular dynamics and EPR spectroscopic studies of 8CB liquid crystal
Soft Matter, 8 (25), 2823-2833, 2012
DOI: 10.1039/c2sm25429h

Oganesyan V.S.
A general approach for prediction of motional EPR spectra from Molecular Dynamics (MD) simulations: application to spin labelled protein
Phys. Chem. Chem. Phys., 13 (10), 4724-4731., 2011 
DOI: 10.1039/C0CP01068E

Kuprusevicius E., White G.F. and Oganesyan V.S.
Prediction of nitroxide spin label EPR spectra from MD trajectories: application to Myoglobin
Faraday Discuss., 148, 283-298, 2011, (selected as Hot Article) 
DOI: 10.1039/C004855K

A. Jablonskytė, J.A. Wright, S.A. Fairhurst, J.N.T. Peck, S.K. Ibrahim, V.S. Oganesyan and C.J. Pickett
Paramagnetic Bridging Hydrides of Relevance to Catalytic Hydrogen Evolution at Metallo-sulfur Centers.
J. Am. Chem. Soc., 133 (46), 18606-9, 2011.
DOI: 10.1021/ja2087536

Kuprusevicius E., Edge R., Gopee H., Cammidge A.N., McInnes E.J.L., Wilson M.R., and Oganesyan V.S.
Prediction of EPR spectra of liquid crystals with doped spin probes from fully atomistic MD simulations: Exploring molecular order and dynamics at the phase transition
Chem. Eur. J., 16, (38), 11558-11562, 2010
DOI: 10.1002/chem.201001439

Oganesyan V.S.*, Kuprusevicius E., Gopee H., Cammidge A.N. and Wilson M.R.
Electron paramagnetic resonance spectra simulation directly from molecular dynamics trajectories of a liquid crystal with a doped paramagnetic spin probe
Phys. Rev. Lett., 102, 013005, 2009.
DOI: 10.1103/PhysRevLett.102.013005

McMaster J. and Oganesyan V.S.
Magnetic Circular Dichroism Spectroscopy as a Probe of the Structures of the Metal Sites in Metalloproteins
Current Opinion. Struct. Biol., 20 (5), 615-622, 2010.
DOI: 10.1016/j.sbi.2010.06.006,

Career

  • 2017-  Reader in Computational Chemistry, School of Chemistry, University of East Anglia 
  • 2012-  Senior Lecturer in Computational Chemistry, School of Chemistry, University of East Anglia
  • 2007-2012  Lecturer in Computational Chemistry, School of Chemistry, University of East Anglia
  • 2004-2009 EPSRC Advanced Research Fellow, School of Chemical Sciences & Pharmacy, University of East Anglia
  • 2000-2004  Senior Research Fellow, School of Chemical Sciences and Pharmacy, UEA
  • 1997-2000  Postdoctoral researcher, School of Chemical Sciences and Pharmacy, UEA, supervisor Prof. A.J. Thomson)  

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