Key Research Interests

We study the developing eye to investigate how cells organise themselves into complex organ systems and to expose the root causes of congenital malformations. A central focus of this work is the investigation of gene regulatory networks that define the multitude of ocular cell types and protein regulatory (signal transduction) networks that coordinate their interactive development.

We employ the chick embryo as an experimental model for the vertebrate camera eye. Our multi-disciplinary approach includes: whole-organ (3-D) in vivo imaging and computational analysis to map dynamic regulatory cell states against the emerging anatomy; molecular and pharmacological perturbation and gene expression profiling of micro-dissected tissue explants in vitro to functionally characterise signalling network interactions and their integration with downstream gene regulatory networks; molecular perturbation of gene and protein regulatory networks in vivo to investigate candidate disease genes and validate molecular network topologies.


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