Biography

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Tharin obtained a BSc in Molecular Sciences and a PhD in Biochemistry from the University of São Paulo (Brazil). Her interests in Structural Biology then took her to Canada, where she used nuclear magnetic resonance (NMR) spectroscopy to study protein structure and dynamics in the regulation of muscle contraction as a postdoctoral fellow in Prof. Brian Sykes’s laboratory, in the University of Alberta, before moving to the UK to work with Prof. Steve Matthews at Imperial College London, where she studied proteins involved in cell invasion by the parasite Toxoplasma gondii.

Research interests in the Blumenschein group involve using NMR spectroscopy to investigate structural and dynamic properties of proteins, and their role in protein interactions and function. Current projects include Chlamydia effectors, cell signalling in cancer, and the cytochrome c, as well as the study of intrinsically disordered proteins by NMR spectroscopy.

Selected publications

J. Tolchard, S. J. Walpole, A. J. Miles, R. Maytum, L. A. Eaglen, T. Hackstadt, B. A. Wallace and T. M. A. Blumenschein.
The intrinsically disordered Tarp protein from Chlamydia binds actin with a partially preformed helix.
Scientific Reports, 2018, 8, 1960.
DOI:10.1038/s41598-018-20290-8

A. I. Karsisiotis, O. M. Deacon, M. T. Wilson, C. Macdonald, T. M. A. Blumenschein, G. R. Moore and J. R. Worrall.
Increased dynamics in the 40-57 Ω-loop of the G41S variant of human cytochrome c promote its pro-apoptotic conformation.
Scientific Reports, 2016, 6, 30447.
DOI:10.1038/srep30447

L. S. Boutemy, S. R. King, J. Win, R. K. Hughes, T. A. Clarke, T. M. A. Blumenschein, S. Kamoun and M. J. Banfield.
Structures of Phytophthora RXLR effector proteins: a conserved but adaptable fold underpins functional diversity.
Journal of Biological Chemistry, 2011, 286, 35834-35842.
DOI: 10.1074/jbc.M111.262303

J. F. de Oliveira, M. L. Sforça, T. M. A. Blumenschein, B. G. Guimarães, C. C. de Oliveira, N. I. T. Zanchin and A.-C. Zeri.
Structure, dynamics and RNA interaction analysis of the human SBDS protein
Journal of Molecular Biology, 2010, 396, 1053-1069.
DOI: 10.1016/j.jmb.2009.12.039

Career

  • 1990-1994 – BSc in Molecular Sciences, University of São Paulo, Brazil
  • 1995-2000 – PhD in Biochemistry, Institute of Chemistry, University of São Paulo, Brazil 
  • 2000-2005 – Postdoctoral Fellow, Department of Biochemistry, University of Alberta, Canada
  • 2005-2007 – Postdoctoral Research Associate, Division of Molecular Biosciences, Imperial College London
  • 2007-current – Lecturer in Biomolecular NMR, School of Chemistry, University of East Anglia

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