Phd Positions

Click here for current PhD opportunities in PHA. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Sheng obtained her BEng. (Hons) in Industrial Pharmacy in 2001 (China Pharmaceutical University). After completing her PhD in 2004 (Queen’s University of Belfast) in the area of lipid based microparticulate drug delivery systems, Sheng worked as a postdoctoral scientist studying the structure and stability of amorphous polymer-drug dispersions. In 2007 Sheng joined the School of Pharmacy at UEA as a lecturer and was promoted to senior lecturer in 2013.  Sheng has worked closely with leading pharmaceutical and excipient companies in the areas of pharmaceutical processing, physicochemical characterisation, and formulation development.

Sheng’s current research interests mainly focus on gaining a fundamental understanding of the behaviour of drug-polymer/lipid dispersions in solid (phase behaviour) and liquid (in biological fluids) states, and developing new approaches for stabilising supersaturated drug dispersions. By working with industrial partners as well as cross-discipline collaborators, her group is aiming to contribute to the interdisciplinary research area of enhancing drug absorption via tailoring the physical chemistry of drug formulations.

Current research interests include

  • Hot melt extrusion/injection moulding for drug delivery
  • Electrospinning and electrospray-formulation design and processing control
  • Drug-polymer/lipid solubility and miscibility
  • Phase separation behaviour of polymer-drug dispersions
  • Polymer facilitated drug solubilisation in biological fluids
  • Lipid-based liquid crystalline platform for drug delivery
  • Effect of manufacturing processes on stability of amorphous pharmaceuticals

Selected Publications

Microstructure of an Immiscible Polymer Blend and Its Stabilization Effect on Amorphous Solid Dispersions
Ziyi Yang, Kathrin Nollenberger, Jessica Albers, Duncan Craig, and Sheng Qi
Molecular Pharmaceutics, Articles ASAP
Publication Date (Web): May 13, 2013 (Article)
DOI: 10.1021/mp400209w

Phase separation in pharmaceutical solid dispersion thin films under high humidity: improved spatial understanding using probe based thermal and spectroscopic nano-characterisation methods.
Sheng Qi, Jonathan G. Moffat, Ziyi Yang.
Molecular Pharmaceutics, 2013.
DOI: 10.1021/mp300557q

Stabilisation of amorphous drugs under high humidity using pharmaceutical thin films.
Yuen Chuen Ng, Ziyi Yang, William James McAuley, Sheng Qi.
European Journal of Pharmaceutics and Biopharmaceutics, 2013.
DOI: 10.1016/j.ejpb.2013.01.008

Insights into the role of polymer-surfactant complexes in drug solubilisation/stabilisation during drug release from solid dispersions.
Sheng Qi, Steve Roser, Karen J. Edler, Claudia Pigliacelli, Ilse Weuts, Marcus Brewster.
Pharmaceutical Research, 2013, 30(1) 290-302
DOI: 10.1007/s11095-012-0873-7

The Development of Modulated, Quasi-Isothermal and Ultraslow Thermal Methods as a Means of Characterizing the ? to ? Indomethacin Polymorphic Transformation.
Sheng Qi, Duncan Q. M. Craig.
Molecular Pharmaceutics, 2012, 9 (5): 1087–1099
DOI: 10.1021/mp2003412

Compositional analysis of low quantities of phase separation in hot melt extruded solid dispersions: a combined atomic force microscopy, photothermal Fourier-transform infrared microspectroscopy and localised thermal analysis approach.
Sheng Qi, Peter Belton, Kathrin Nollenberger, Andreas Gryczke, Duncan Q.M. Craig
Pharmaceutical Research, 2011, 1-16
DOI: 10.1007/s11095-011-0461-2

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