Key Research Interests

Our overarching research interest is the role ion channels and receptors play in the cellular and molecular mechanisms that underlie cardiometabolic physiology and disease with an emphasis of blood vessels, adipose tissue and the peripheral nervous system.

Vascular pharmacology & physiology We are interested in the role of the peripheral nervous system in controlling human arterial and venous blood flow, in additional to the role of vascular endothelium in the mechanical detection of blood flow.

Adipose biology and dysfunction  We are interested in the role of efferent and afferent nervous innervation of human white adipose tissue and regulatory changes associated with metabolic disease. 

Receptor-ligand interactions and drug discovery We have an active programme to investigate novel molecules that allosterically modulate human P2X receptors (a family of ligand-gated ion channels). We are interested in the identification (via HTS) and molecular interaction of (in silico docking, receptor-ligand SAR) small molecules, natural products and antibodies with human P2X receptors.

Our research programme is generously funded by the British Heart Foundation, BBSRC, Merck and AstraZeneca.

 

Major experimental techniques available in the lab

 

Pressure myography using human and animal arteries

Wire myography using human and animal arteries

Single-cell calcium imaging

Manual patch-clamp electrophysiology

Planar patch-clamp electrophysiology

Extracellular neurophysiological recordings

High throughput compound screens (Flexstation)

 

Research Group Membership

Samuel J. Fountain BSc PhD FHEA (Principal Investigator)

 

Research Associates

 

Dr Maria del Carmen Gonzalez-Montelongo (BHF funded Senior Research Associate)

Dr Neville Ngum (BHF funded Senior Research Associate)

Dr Stefan Bidula (BHF funded Senior Research Associate)

 

Postgraduate Research Students

 

PhD Students 

Michelle Fletcher (BBSRC iCASE with AstraZeneca) (2019 - 2023)

Sonia Paz BSc (BBSRC DTP Studentship) (2019 - 2023)

Jessica Meades BSc (BBSRC iCASE Studentship with Merck, USA) (2018 - 2022)

Anna Fortuny Gomez BSc (BBSRC DTP Studentship) (2018 - 2022)

Dalyan Eldaly (Article 26 studentship) (2018 - 2021) 

 

Masters by Research

Sean Cullum BSc

Harry Hickey BSc

 

PhD Positions

Click here for current PhD opportunities in Biological Sciences. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

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