Key Research Interests and Expertise

Having trained as a biochemist, my research interests have broadened out to encompass methodologies that involve biophysical chemistry, microbiology and molecular biology. More recently, I have even dabbled with bioinformatics and structural biology! My research has focused on macromolecular interactions of bacterial DNA repair proteins, particularly DNA and RNA ligases. Our experiments are performed in vitro or in bacterial model organisms. 

Current Research Projects

  • Physiological functions of DNA ligases
  • RNA ligases of bacteria and viruses
  • DNA repair pathways of model organisms
  • Relationship between DNA metabolism and genetic instability of DNA repeats 

Life in our research group 

We use a range of contemporary biochemical and molecular biological techniques that allow us to study the relationship between DNA metabolism and processes that take place within cells. Our experiments take advantage of well-characterised model organisms, providing great opportunities to link our understanding of biochemical mechanisms to physiological consequences. Much of our work focused on microorganisms, but recent projects use proteins, cells or tissues from higher organisms, including humans. The majority of our experiments are conducted in a laboratory that is shared with other research groups at UEA that have a biochemical and structural biological focus. We regularly host visitors from our international collaborators.  

Video

ID: 19372