Key Research Interests and Expertise

**PhD studentships available - contact me for more details**

The prevalence of immune cells and mediators as major regulatory factors in skeletal biology has become increasingly evident in the last 20 years yet the complexity of the various interactions continues to provide challenges for immunologists and bone biologists world-wide.  Osteoimmunology seeks to define the roles and interactions of immune cells with skeletal cells and to identify shared pathways and signalling molecules.  By understanding these interactions and mediators, my lab aims to apply this clinically for the treatment of bone cancers and metastases, inflammatory arthritis, osteoporosis, and periodontitis.

Current Research Questions

  1. Determining the role of natural killer cells in the initiation of autoimmunity.
  2. How inflammation can cause both bone destruction and bone formation in ankylosing spondylitis?
  3. How the tissue repair cycle is initiated and what happens if it fails to switch off?  What are the roles of different macrophage subsets in bone turnover?
  4. What factors control bone marrow cell fate and their correlation to disease susceptibility in the aged?
  5. Are there ways to reprogram bone forming osteoblasts to produce more bone?
  6. Altering the bone microenvironment in bone marrow cancers to reduce disease burden and preserve bone architecture.
  7. How to separate the anti-inflammatory properties of glucocorticoids from their adverse effects on bone destruction?
  8. Ways to speed fracture repair in healthy and osteoporotic bone

ID: 147418123