Biography

Leanne obtained a first class BSc (Dual Honours) in Physiology & Pharmacology from the University of Sheffield in 1999 and continued to study an MRes (MPhil) in Immunology & oncology at the University of Birmingham (2000). She stayed at the University of Birmingham to do a PhD in Immunology under the supervision of Professor John Gordon and Dr Gillian Grafton.

Following her interests in ion channels in immune cells, Leanne began a post-doctoral position in the lab of Professor Annmarie Surprenant at the University of Sheffield (2003-2006) investigating purinergic ion channels. A further post-doctoral position at the University of Sydney with Professor James Wiley (2007-2010) led to independence as a research fellow at the University of Sydney (2010-2013) followed by a prestigious Vice Chancellor’s research fellowship at RMIT University in Melbourne (2013-2015). 

Selected publications

Helliwell RM, ShioukHuey C O, Dhuna K, Molero JC, Ye J-M, Xue CC, Stokes L.
Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P2X7 receptors.
Br J Pharm. 2015 Epub ahead
DOI: 10.1111/bph.13123.

Bartlett R, Stokes L, Sluyter R.
The P2X7 purinergic receptor: recent developments and the use of P2X7 antagonists in models of disease.
Pharmacological Reviews 2014 66(3):638-75.
DOI: 10.1124/pr.113.008003.

Bhaskaracharya A, Dao-Ung P, Spildrejorde M, Jalilian I, Skarratt KK, Fuller SJ, Sluyter R, Stokes L.
Probenecid blocks P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism.
PLoS One 2014 9(3):e93058.
DOI: 10.1371/journal.pone.0093058

Stokes L, Scurrah K, Ellis JA, Cromer BA, Skarratt KK, Gu BJ, Harrap SB, Wiley JS.
A loss-of-function polymorphism in the human P2X4 receptor is associated with increased pulse pressure.
Hypertension 2011 58(6):1086-92.
DOI: 10.1161/HYPERTENSIONAHA.111.176180

Stokes L, Fuller SJ, Sluyter R, Skarratt KK, Gu B, Wiley JS.
Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1b secretion.
FASEB Journal. 2010 24(8): 2916-27.
DOI: 10.1096/fj.09-150862

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