1. 2020
  2. Published

    Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics

    Bhagwan, J. R., Mosqueira, D., Chairez-Cantu, K., Mannhardt, I., Bodbin, S. E., Bakar, M., Smith, J. G. W. & Denning, C., Aug 2020, In : Journal of Molecular and Cellular Cardiology. 145, p. 43-53 11 p.

    Research output: Contribution to journalArticle

  3. Published

    Mitochondrial DNA: Hotspot for potential gene modifiers regulating hypertrophic cardiomyopathy

    Kargaran, P. K., Evans, J. M., Bodbin, S. E., Smith, J. G. W., Nelson, T. J., Denning, C. & Mosqueira, D., 23 Jul 2020, In : Journal of Clinical Medicine. 9, 8

    Research output: Contribution to journalArticle

  4. E-pub ahead of print

    Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour

    Bhagwan, J. R., Collins, E., Mosqueira, D., Bakar, M., Johnson, B. B., Thompson, A., Smith, J. G. W. & Denning, C., 10 Jul 2020, In : F1000Research. 8, 1911.

    Research output: Contribution to journalArticle

  5. 2019
  6. Published

    ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection

    Mistry, J. J., Marlein, C. R., Moore, J. A., Hellmich, C., Wojtowicz, E. E., Smith, J. G. W., Macaulay, I., Sun, Y., Morfakis, A., Patterson, A., Horton, R. H., Divekar, D., Morris, C. J., Haestier, A., Di Palma, F., Beraza, N., Bowles, K. M. & Rushworth, S. A., 3 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24610-24619 10 p.

    Research output: Contribution to journalArticle

  7. E-pub ahead of print

    Modeling Hypertrophic Cardiomyopathy: Mechanistic Insights and Pharmacological Intervention

    Mosqueira, D., Smith, J., Bhagwan, J. R. & Denning, C., 17 Jul 2019, In : Trends in Molecular Medicine.

    Research output: Contribution to journalReview article

  8. 2018
  9. Published

    CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy

    Mosqueira, D., Mannhardt, I., Bhagwan, J. R., Lis-Slimak, K., Katili, P., Scott, E., Hassan, M., Prondzynski, M., Harmer, S. C., Tinker, A., Smith, J. G. W., Carrier, L., Williams, P. M., Gaffney, D., Eschenhagen, T., Hansen, A. & Denning, C., 14 Nov 2018, In : European Heart Journal. 39, 43, p. 3879-3892 14 p.

    Research output: Contribution to journalArticle

  10. Published

    Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits

    Smith, J. G. W., Owen, T., Bhagwan, J. R., Mosqueira, D., Scott, E., Mannhardt, I., Patel, A., Barriales-Villa, R., Monserrat, L., Hansen, A., Eschenhagen, T., Harding, S. E., Marston, S. & Denning, C., 13 Nov 2018, In : Stem Cell Reports. 11, 5, p. 1226-1243 18 p.

    Research output: Contribution to journalArticle

  11. Published

    The multifaceted roles of perlecan in fibrosis

    Lord, M. S., Tang, F., Rnjak-Kovacina, J., Smith, J., Melrose, J. & Whitelock, J. M., Aug 2018, In : Matrix Biology. 68-69, p. 150-166 17 p.

    Research output: Contribution to journalArticle

  12. Published

    Simplified footprint-free Cas9/CRISPR editing of cardiac-associated genes in human pluripotent stem cells

    Kondrashov, A., Hoang, M. D., Smith, J. G. W., Bhagwan, J. R., Duncan, G., Mosqueira, D., Munoz, M. B., Vo, N. T. N. & Denning, C., 12 Mar 2018, In : Stem Cells and Development. 27, 6, p. 391-404 14 p.

    Research output: Contribution to journalArticle

  13. 2016
  14. Published

    Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion

    Hammad, M., Rao, W., Smith, J. G. W., Anderson, D. G., Langer, R., Young, L. E., Barrett, D. A., Davies, M. C., Denning, C. & Alexander, M. R., 28 Jul 2016, In : Biomaterials Science. 4, 9, p. 1381-1391

    Research output: Contribution to journalArticle

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