HomePublications

Vitamin B-6 intake is related to physical performance in European older adults: results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) study

Research output: Contribution to journalArticle

Open Access permissions

Open

Documents

Links

DOI

Authors

  • Pol Grootswagers
  • Marco Mensink
  • Agnes A. M. Berendsen
  • Carolien P. J. Deen
  • Ido P. Kema
  • Stephan J. L. Bakker
  • Aurelia Santoro
  • Claudio Franceschi
  • Nathalie Meunier
  • Corinne Malpuech-Brugère
  • Agata Bialecka-Debek
  • Katarzyna Rolf
  • Susan Fairweather-Tait
  • Amy Jennings
  • Edith J. M. Feskens
  • Lisette C. P. G. M. De groot

Organisational units

Abstract

BACKGROUND: Maintenance of high physical performance during aging might be supported by an adequate dietary intake of niacin, vitamins B-6 and B-12, and folate because these B vitamins are involved in multiple processes related to muscle functioning. However, not much is known about the association between dietary intake of these B vitamins and physical performance. OBJECTIVES: The objectives of this study were to investigate the association between dietary intake of niacin, vitamins B-6 and B-12, and folate and physical performance in older adults and to explore mediation by niacin status and homocysteine concentrations. METHODS: We used baseline data from the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) trial, which included n = 1249 healthy older adults (aged 65-79 y) with complete data on dietary intake measured with 7-d food records and questionnaires on vitamin supplement use and physical performance measured with the short physical performance battery and handgrip dynamometry. Associations were assessed by adjusted linear mixed models. RESULTS: Intake of vitamin B-6 was related to lower chair rise test time [β: -0.033 ± 0.016 s (log); P = 0.043]. Vitamin B-6 intake was also significantly associated with handgrip strength, but for this association, a significant interaction effect between vitamin B-6 intake and physical activity level was found. In participants with the lowest level of physical activity, higher intake of vitamin B-6 tended to be associated with greater handgrip strength (β: 1.5 ± 0.8 kg; P = 0.051), whereas in participants in the highest quartile of physical activity, higher intake was associated with lower handgrip strength (β: -1.4 ± 0.7 kg; P = 0.041). No evidence was found for an association between intake of niacin, vitamin B-12, or folate and physical performance or for mediation by niacin status or homocysteine concentrations. CONCLUSIONS: Vitamin B-6 intake was associated with better chair rise test time in a population of European healthy older adults and also with greater handgrip strength in participants with low physical activity only. Homocysteine concentrations did not mediate these associations. The NU-AGE trial was registered at clinicaltrials.gov as NCT01754012.

Details

Original languageEnglish
Pages (from-to)781–789
Number of pages9
JournalThe American Journal of Clinical Nutrition
Volume113
Issue number4
Early online date29 Jan 2021
DOIs
Publication statusPublished - Apr 2021
Peer-reviewedYes

Keywords

    Research areas

  • folate, homocysteine, muscle, niacin, physical function, vitamin B-12, vitamin B-6

View graph of relations

ID: 186004313