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The multifaceted roles of perlecan in fibrosis

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Authors

  • Megan S. Lord
  • Fengying Tang
  • Jelena Rnjak-Kovacina
  • James Smith
  • James Melrose
  • John M. Whitelock

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Abstract

Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and organ development and wound healing by orchestrating the binding and signaling of mitogens and morphogens to cells in a temporal and dynamic fashion. In this review, its roles in fibrosis are reviewed by drawing upon evidence from tissue and organ systems that undergo fibrosis as a result of an uncontrolled response to either inflammation or traumatic cellular injury leading to an over production of a collagen-rich extracellular matrix. This review focuses on examples of fibrosis that occurs in lung, liver, kidney, skin, kidney, neural tissues and blood vessels and its link to the expression of perlecan in that particular organ system.

Details

Original languageEnglish
Pages (from-to)150-166
Number of pages17
JournalMatrix Biology
Volume68-69
Early online date20 Feb 2018
DOIs
Publication statusPublished - Aug 2018
Peer-reviewedYes

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