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The β3‐integrin endothelial adhesome regulates microtubule‐dependent cell migration

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The β3‐integrin endothelial adhesome regulates microtubule‐dependent cell migration. / Atkinson, Samuel J.; Gontarczyk, Aleksander M.; Alghamdi, Abdullah AA; Ellison, Tim S.; Johnson, Robert T.; Fowler, Wesley J.; Kirkup, Benjamin M.; Silva, Bernardo C.; Harry, Bronwen E.; Schneider, Jochen G.; Weilbaecher, Katherine N.; Mogensen, Mette M.; Bass, Mark D.; Parsons, Maddy ; Edwards, Dylan R.; Robinson, Stephen D.

In: EMBO reports, Vol. 19, No. 6, e44578, 01.06.2018.

Research output: Contribution to journalArticle

Harvard

Atkinson, SJ, Gontarczyk, AM, Alghamdi, AAA, Ellison, TS, Johnson, RT, Fowler, WJ, Kirkup, BM, Silva, BC, Harry, BE, Schneider, JG, Weilbaecher, KN, Mogensen, MM, Bass, MD, Parsons, M, Edwards, DR & Robinson, SD 2018, 'The β3‐integrin endothelial adhesome regulates microtubule‐dependent cell migration' EMBO reports, vol 19, no. 6, e44578. DOI: 10.15252/embr.201744578

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Atkinson, Samuel J. ; Gontarczyk, Aleksander M. ; Alghamdi, Abdullah AA ; Ellison, Tim S. ; Johnson, Robert T. ; Fowler, Wesley J. ; Kirkup, Benjamin M. ; Silva, Bernardo C. ; Harry, Bronwen E. ; Schneider, Jochen G. ; Weilbaecher, Katherine N. ; Mogensen, Mette M. ; Bass, Mark D. ; Parsons, Maddy ; Edwards, Dylan R. ; Robinson, Stephen D./ The β3‐integrin endothelial adhesome regulates microtubule‐dependent cell migration. In: EMBO reports. 2018 ; Vol. 19, No. 6.

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@article{c3b100673f874ead96ce74d95cffca09,
title = "The β3‐integrin endothelial adhesome regulates microtubule‐dependent cell migration",
abstract = "Integrin β3 is seen as a key anti-angiogenic target for cancer treatment due to its expression on neovasculature, but the role it plays in the process is complex; whether it is pro- or anti-angiogenic depends on the context in which it is expressed. To understand precisely β3’s role in regulating integrin adhesion complexes in endothelial cells, we characterised, by mass spectrometry, the β3-dependent adhesome. We show that depletion of β3-integrin in this cell type leads to changes in microtubule behaviour that control cell migration. β3-integrin regulates microtubule stability in endothelial cells through Rcc2/Anxa2 driven control of active Rac1 localisation. Our findings reveal that angiogenic processes, both in vitro and in vivo, are more sensitive to microtubule targeting agents when β3-integrin levels are reduced",
keywords = "adhesive, endothelial, integrins, microtubules",
author = "Atkinson, {Samuel J.} and Gontarczyk, {Aleksander M.} and Alghamdi, {Abdullah AA} and Ellison, {Tim S.} and Johnson, {Robert T.} and Fowler, {Wesley J.} and Kirkup, {Benjamin M.} and Silva, {Bernardo C.} and Harry, {Bronwen E.} and Schneider, {Jochen G.} and Weilbaecher, {Katherine N.} and Mogensen, {Mette M.} and Bass, {Mark D.} and Maddy Parsons and Edwards, {Dylan R.} and Robinson, {Stephen D.}",
year = "2018",
month = "6",
day = "1",
doi = "10.15252/embr.201744578",
language = "English",
volume = "19",
journal = "EMBO reports",
issn = "1469-221X",
publisher = "Nature Publishing Group",
number = "6",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - The β3‐integrin endothelial adhesome regulates microtubule‐dependent cell migration

AU - Atkinson,Samuel J.

AU - Gontarczyk,Aleksander M.

AU - Alghamdi,Abdullah AA

AU - Ellison,Tim S.

AU - Johnson,Robert T.

AU - Fowler,Wesley J.

AU - Kirkup,Benjamin M.

AU - Silva,Bernardo C.

AU - Harry,Bronwen E.

AU - Schneider,Jochen G.

AU - Weilbaecher,Katherine N.

AU - Mogensen,Mette M.

AU - Bass,Mark D.

AU - Parsons,Maddy

AU - Edwards,Dylan R.

AU - Robinson,Stephen D.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Integrin β3 is seen as a key anti-angiogenic target for cancer treatment due to its expression on neovasculature, but the role it plays in the process is complex; whether it is pro- or anti-angiogenic depends on the context in which it is expressed. To understand precisely β3’s role in regulating integrin adhesion complexes in endothelial cells, we characterised, by mass spectrometry, the β3-dependent adhesome. We show that depletion of β3-integrin in this cell type leads to changes in microtubule behaviour that control cell migration. β3-integrin regulates microtubule stability in endothelial cells through Rcc2/Anxa2 driven control of active Rac1 localisation. Our findings reveal that angiogenic processes, both in vitro and in vivo, are more sensitive to microtubule targeting agents when β3-integrin levels are reduced

AB - Integrin β3 is seen as a key anti-angiogenic target for cancer treatment due to its expression on neovasculature, but the role it plays in the process is complex; whether it is pro- or anti-angiogenic depends on the context in which it is expressed. To understand precisely β3’s role in regulating integrin adhesion complexes in endothelial cells, we characterised, by mass spectrometry, the β3-dependent adhesome. We show that depletion of β3-integrin in this cell type leads to changes in microtubule behaviour that control cell migration. β3-integrin regulates microtubule stability in endothelial cells through Rcc2/Anxa2 driven control of active Rac1 localisation. Our findings reveal that angiogenic processes, both in vitro and in vivo, are more sensitive to microtubule targeting agents when β3-integrin levels are reduced

KW - adhesive

KW - endothelial

KW - integrins

KW - microtubules

U2 - 10.15252/embr.201744578

DO - 10.15252/embr.201744578

M3 - Article

VL - 19

JO - EMBO reports

T2 - EMBO reports

JF - EMBO reports

SN - 1469-221X

IS - 6

M1 - e44578

ER -

ID: 133450514