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The β3‐integrin endothelial adhesome regulates microtubule‐dependent cell migration

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Abstract

Integrin β3 is seen as a key anti-angiogenic target for cancer treatment due to its expression on neovasculature, but the role it plays in the process is complex; whether it is pro- or anti-angiogenic depends on the context in which it is expressed. To understand precisely β3’s role in regulating integrin adhesion complexes in endothelial cells, we characterised, by mass spectrometry, the β3-dependent adhesome. We show that depletion of β3-integrin in this cell type leads to changes in microtubule behaviour that control cell migration. β3-integrin regulates microtubule stability in endothelial cells through Rcc2/Anxa2 driven control of active Rac1 localisation. Our findings reveal that angiogenic processes, both in vitro and in vivo, are more sensitive to microtubule targeting agents when β3-integrin levels are reduced

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Original languageEnglish
Article numbere44578
JournalEMBO reports
Volume19
Issue number6
Early online date24 May 2018
DOIs
Publication statusPublished - 1 Jun 2018
Peer-reviewedYes

Keywords

    Research areas

  • adhesive, endothelial, integrins, microtubules

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