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Sensitivity of negative subsequent memory and task-negative effects to age and associative memory performance

Research output: Contribution to journalArticle

Authors

  • Marianne de Chastelaine
  • Julia T. Mattson
  • Tracy H. Wang
  • Brian E. Donley
  • Michael D. Rugg

Abstract

The present fMRI experiment employed associative recognition to investigate the relationships between age and encoding-related negative subsequent memory effects and task-negative effects. Young, middle-aged and older adults (total n=136) were scanned while they made relational judgments on visually presented word pairs. In a later memory test, the participants made associative recognition judgments on studied, rearranged (items studied on different trials) and new pairs. Several regions, mostly localized to the default mode network, demonstrated negative subsequent memory effects in an across age-group analysis. All but one of these regions also demonstrated task-negative effects, although there was no correlation between the size of the respective effects. Whereas negative subsequent memory effects demonstrated a graded attenuation with age, task-negative effects declined markedly between the young and the middle-aged group, but showed no further reduction in the older group. Negative subsequent memory effects did not correlate with memory performance within any age group. By contrast, in the older group only, task-negative effects predicted later memory performance. The findings demonstrate that negative subsequent memory and task-negative effects depend on dissociable neural mechanisms and likely reflect distinct cognitive processes. The relationship between task-negative effects and memory performance in the older group might reflect the sensitivity of these effects to variations in amount of age-related neuropathology.

Details

Original languageEnglish
Pages (from-to)16-29
JournalBehavioural Brain Research
Volume1612
Early online date28 Sep 2014
DOIs
Publication statusPublished - 1 Jul 2015
Peer-reviewedYes
Externally publishedYes

Keywords

    Research areas

  • fMRI, Aging, Associative recognition, Memory encoding, Recollection

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