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Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure

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Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure. / De Santis, Stefania; Galleggiante, Vanessa; Scandiffio, Letizia; Liso, Marina; Sommella, Eduardo; Sobolewski, Anastasia; Spilotro, Vito; Pinto, Aldo; Campiglia, Pietro; Serino, Grazia; Santino, Angelo; Notarnicola, Maria; Chieppa, Marcello.

In: Nutrients, Vol. 9, No. 7, 706, 06.07.2017.

Research output: Contribution to journalArticle

Harvard

De Santis, S, Galleggiante, V, Scandiffio, L, Liso, M, Sommella, E, Sobolewski, A, Spilotro, V, Pinto, A, Campiglia, P, Serino, G, Santino, A, Notarnicola, M & Chieppa, M 2017, 'Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure', Nutrients, vol. 9, no. 7, 706. https://doi.org/10.3390/nu9070706

APA

De Santis, S., Galleggiante, V., Scandiffio, L., Liso, M., Sommella, E., Sobolewski, A., Spilotro, V., Pinto, A., Campiglia, P., Serino, G., Santino, A., Notarnicola, M., & Chieppa, M. (2017). Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure. Nutrients, 9(7), [706]. https://doi.org/10.3390/nu9070706

Vancouver

Author

De Santis, Stefania ; Galleggiante, Vanessa ; Scandiffio, Letizia ; Liso, Marina ; Sommella, Eduardo ; Sobolewski, Anastasia ; Spilotro, Vito ; Pinto, Aldo ; Campiglia, Pietro ; Serino, Grazia ; Santino, Angelo ; Notarnicola, Maria ; Chieppa, Marcello. / Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure. In: Nutrients. 2017 ; Vol. 9, No. 7.

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@article{2e63680306894d8faa926551cdf22e4e,
title = "Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure",
abstract = "Dendritic cells{\textquoteright} (DCs) ability to present antigens and initiate the adaptive immune response confers them a pivotal role in immunological defense against hostile infection and, at the same time, immunological tolerance towards harmless components of the microbiota. Food products can modulate the inflammatory status of intestinal DCs. Among nutritionally-derived products, we investigated the ability of quercetin to suppress inflammatory cytokines secretion, antigen presentation, and DCs migration towards the draining lymph nodes. We recently identified the Slpi expression as a crucial checkpoint required for the quercetin-induced inflammatory suppression. Here we demonstrate that Slpi-KO DCs secrete a unique panel of cytokines and chemokines following quercetin exposure. In vivo, quercetin-enriched food is able to induce Slpi expression in the ileum, while little effects are detectable in the duodenum. Furthermore, Slpi expressing cells are more frequent at the tip compared to the base of the intestinal villi, suggesting that quercetin exposure could be more efficient for DCs projecting periscopes in the intestinal lumen. These data suggest that quercetin-enriched nutritional regimes may be efficient for suppressing inflammatory syndromes affecting the ileo-colonic tract.",
keywords = "quercetin, dendritic cells, Slpi, inflammation",
author = "{De Santis}, Stefania and Vanessa Galleggiante and Letizia Scandiffio and Marina Liso and Eduardo Sommella and Anastasia Sobolewski and Vito Spilotro and Aldo Pinto and Pietro Campiglia and Grazia Serino and Angelo Santino and Maria Notarnicola and Marcello Chieppa",
year = "2017",
month = jul,
day = "6",
doi = "10.3390/nu9070706",
language = "English",
volume = "9",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "7",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Secretory Leukoprotease Inhibitor (Slpi) Expression Is Required for Educating Murine Dendritic Cells Inflammatory Response Following Quercetin Exposure

AU - De Santis, Stefania

AU - Galleggiante, Vanessa

AU - Scandiffio, Letizia

AU - Liso, Marina

AU - Sommella, Eduardo

AU - Sobolewski, Anastasia

AU - Spilotro, Vito

AU - Pinto, Aldo

AU - Campiglia, Pietro

AU - Serino, Grazia

AU - Santino, Angelo

AU - Notarnicola, Maria

AU - Chieppa, Marcello

PY - 2017/7/6

Y1 - 2017/7/6

N2 - Dendritic cells’ (DCs) ability to present antigens and initiate the adaptive immune response confers them a pivotal role in immunological defense against hostile infection and, at the same time, immunological tolerance towards harmless components of the microbiota. Food products can modulate the inflammatory status of intestinal DCs. Among nutritionally-derived products, we investigated the ability of quercetin to suppress inflammatory cytokines secretion, antigen presentation, and DCs migration towards the draining lymph nodes. We recently identified the Slpi expression as a crucial checkpoint required for the quercetin-induced inflammatory suppression. Here we demonstrate that Slpi-KO DCs secrete a unique panel of cytokines and chemokines following quercetin exposure. In vivo, quercetin-enriched food is able to induce Slpi expression in the ileum, while little effects are detectable in the duodenum. Furthermore, Slpi expressing cells are more frequent at the tip compared to the base of the intestinal villi, suggesting that quercetin exposure could be more efficient for DCs projecting periscopes in the intestinal lumen. These data suggest that quercetin-enriched nutritional regimes may be efficient for suppressing inflammatory syndromes affecting the ileo-colonic tract.

AB - Dendritic cells’ (DCs) ability to present antigens and initiate the adaptive immune response confers them a pivotal role in immunological defense against hostile infection and, at the same time, immunological tolerance towards harmless components of the microbiota. Food products can modulate the inflammatory status of intestinal DCs. Among nutritionally-derived products, we investigated the ability of quercetin to suppress inflammatory cytokines secretion, antigen presentation, and DCs migration towards the draining lymph nodes. We recently identified the Slpi expression as a crucial checkpoint required for the quercetin-induced inflammatory suppression. Here we demonstrate that Slpi-KO DCs secrete a unique panel of cytokines and chemokines following quercetin exposure. In vivo, quercetin-enriched food is able to induce Slpi expression in the ileum, while little effects are detectable in the duodenum. Furthermore, Slpi expressing cells are more frequent at the tip compared to the base of the intestinal villi, suggesting that quercetin exposure could be more efficient for DCs projecting periscopes in the intestinal lumen. These data suggest that quercetin-enriched nutritional regimes may be efficient for suppressing inflammatory syndromes affecting the ileo-colonic tract.

KW - quercetin

KW - dendritic cells

KW - Slpi

KW - inflammation

U2 - 10.3390/nu9070706

DO - 10.3390/nu9070706

M3 - Article

VL - 9

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 7

M1 - 706

ER -

ID: 114258364