HomePublications

Resistance to natural and synthetic gene drive systems

Research output: Contribution to journalReview article

Open Access permissions

Open

Documents

DOI

Authors

  • Tom A. R. Price
  • Nikolai Windbichler
  • Robert L. Unckless
  • Andreas Sutter
  • Jan Niklas Runge
  • Perran A. Ross
  • Andrew Pomiankowski
  • Nicole L. Nuckolls
  • Catherine Montchamp-Moreau
  • Nicole Mideo
  • Oliver Y. Martin
  • Andri Manser
  • Mathieu Legros
  • Amanda M. Larracuente
  • Luke Holman
  • John Godwin
  • Neil Gemmell
  • Cécile Courret
  • Anna Buchman
  • Luke G. Barrett
  • And 1 others
  • Anna K. Lindholm

Organisational units

Abstract

Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.

Details

Original languageEnglish
Pages (from-to)1345-1360
Number of pages16
JournalJournal of Evolutionary Biology
Volume33
Issue number10
Early online date24 Sep 2020
DOIs
Publication statusPublished - 1 Oct 2020
Peer-reviewedYes

Keywords

    Research areas

  • CRISPR-Cas9, fitness costs, meiotic drive, population suppression, selfish genetic elements, sex ratio distorter, transposable element, Wolbachia

View graph of relations

ID: 184521595

Related by journal
  1. Satyrization in Drosophila fruitflies

    Research output: Contribution to journalArticle

  2. Artificial selection for increased dispersal results in lower fitness

    Research output: Contribution to journalArticle

  3. No selection for change in polyandry under experimental evolution

    Research output: Contribution to journalArticle