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In vitro drug release from acetylated high amylose starch-zein films for oral colon-specific drug delivery

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In vitro drug release from acetylated high amylose starch-zein films for oral colon-specific drug delivery. / Bisharat, Lorina; Barker, Susan A.; Narbad, Arjan; Craig, Duncan Q.M.

In: International Journal of Pharmaceutics, Vol. 556, 10.02.2019, p. 311-319.

Research output: Contribution to journalArticle

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Bisharat, L, Barker, SA, Narbad, A & Craig, DQM 2019, 'In vitro drug release from acetylated high amylose starch-zein films for oral colon-specific drug delivery' International Journal of Pharmaceutics, vol 556, pp. 311-319. DOI: 10.1016/j.ijpharm.2018.12.021

APA

Bisharat, L., Barker, S. A., Narbad, A., & Craig, D. Q. M. (2019). In vitro drug release from acetylated high amylose starch-zein films for oral colon-specific drug delivery. International Journal of Pharmaceutics, 556, 311-319. DOI: 10.1016/j.ijpharm.2018.12.021

Vancouver

Bisharat L, Barker SA, Narbad A, Craig DQM. In vitro drug release from acetylated high amylose starch-zein films for oral colon-specific drug delivery. International Journal of Pharmaceutics. 2019 Feb 10;556:311-319. Available from, DOI: 10.1016/j.ijpharm.2018.12.021

Author

Bisharat, Lorina ; Barker, Susan A. ; Narbad, Arjan ; Craig, Duncan Q.M./ In vitro drug release from acetylated high amylose starch-zein films for oral colon-specific drug delivery. In: International Journal of Pharmaceutics. 2019 ; Vol. 556. pp. 311-319

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@article{43b6d4c11b3b48908ed5663db1cb9e25,
title = "In vitro drug release from acetylated high amylose starch-zein films for oral colon-specific drug delivery",
abstract = "This study describes the preparation of free films of zein with and without acetylated high amylose maize starch (HAS) and their corresponding coated tablets as a novel approach to colonic drug delivery. We hypothesise that the embedding of a digestible starch component within the inert zein would allow the film to remain intact until the large intestine is reached. Free films of zein alone and starch/zein were prepared and characterised. SEM and AFM images of film surface showed that films were morphologically inhomogeneous, particularly at lower HAS/Zein ratios; however, nanothermal analysis data suggested that these differences in appearance within the same film are not compositional differences, i.e. the systems are not phase-separated. Moreover, FT-IR could detect no molecular interaction between the two polymers. Paracetamol tablets were coated with HAS/Zein aqueous based coatings of different compositions to a TWG of 20{\%}. Drug release from zein alone and 1:5 HAS/Zein coated tablets under upper gastrointestinal conditions (pH 1.2, pH 6.8 with pepsin and pancreatin included) was very similar (for example approximately 12{\%} and 14{\%} of the drug was released, respectively, after 6 hours in a sequential in vitro test), suggesting that release in this region is limited and is not influenced by the presence of HAS in the ratio to zein under study. Studies using an in vitro colon model showed that under simulated colonic conditions, the drug release was significantly (p < 0.05) more rapid from 1:5 HAS/Zein, compared to the zein alone coating formulation. These data therefore support the potential use of zein-starch mixed films for colonic targeting purposes.",
keywords = "Zein, Amylose, Starch, Colonic, Drug delivery, Fermentation studies",
author = "Lorina Bisharat and Barker, {Susan A.} and Arjan Narbad and Craig, {Duncan Q.M.}",
year = "2019",
month = "2",
day = "10",
doi = "10.1016/j.ijpharm.2018.12.021",
language = "English",
volume = "556",
pages = "311--319",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - In vitro drug release from acetylated high amylose starch-zein films for oral colon-specific drug delivery

AU - Bisharat,Lorina

AU - Barker,Susan A.

AU - Narbad,Arjan

AU - Craig,Duncan Q.M.

PY - 2019/2/10

Y1 - 2019/2/10

N2 - This study describes the preparation of free films of zein with and without acetylated high amylose maize starch (HAS) and their corresponding coated tablets as a novel approach to colonic drug delivery. We hypothesise that the embedding of a digestible starch component within the inert zein would allow the film to remain intact until the large intestine is reached. Free films of zein alone and starch/zein were prepared and characterised. SEM and AFM images of film surface showed that films were morphologically inhomogeneous, particularly at lower HAS/Zein ratios; however, nanothermal analysis data suggested that these differences in appearance within the same film are not compositional differences, i.e. the systems are not phase-separated. Moreover, FT-IR could detect no molecular interaction between the two polymers. Paracetamol tablets were coated with HAS/Zein aqueous based coatings of different compositions to a TWG of 20%. Drug release from zein alone and 1:5 HAS/Zein coated tablets under upper gastrointestinal conditions (pH 1.2, pH 6.8 with pepsin and pancreatin included) was very similar (for example approximately 12% and 14% of the drug was released, respectively, after 6 hours in a sequential in vitro test), suggesting that release in this region is limited and is not influenced by the presence of HAS in the ratio to zein under study. Studies using an in vitro colon model showed that under simulated colonic conditions, the drug release was significantly (p < 0.05) more rapid from 1:5 HAS/Zein, compared to the zein alone coating formulation. These data therefore support the potential use of zein-starch mixed films for colonic targeting purposes.

AB - This study describes the preparation of free films of zein with and without acetylated high amylose maize starch (HAS) and their corresponding coated tablets as a novel approach to colonic drug delivery. We hypothesise that the embedding of a digestible starch component within the inert zein would allow the film to remain intact until the large intestine is reached. Free films of zein alone and starch/zein were prepared and characterised. SEM and AFM images of film surface showed that films were morphologically inhomogeneous, particularly at lower HAS/Zein ratios; however, nanothermal analysis data suggested that these differences in appearance within the same film are not compositional differences, i.e. the systems are not phase-separated. Moreover, FT-IR could detect no molecular interaction between the two polymers. Paracetamol tablets were coated with HAS/Zein aqueous based coatings of different compositions to a TWG of 20%. Drug release from zein alone and 1:5 HAS/Zein coated tablets under upper gastrointestinal conditions (pH 1.2, pH 6.8 with pepsin and pancreatin included) was very similar (for example approximately 12% and 14% of the drug was released, respectively, after 6 hours in a sequential in vitro test), suggesting that release in this region is limited and is not influenced by the presence of HAS in the ratio to zein under study. Studies using an in vitro colon model showed that under simulated colonic conditions, the drug release was significantly (p < 0.05) more rapid from 1:5 HAS/Zein, compared to the zein alone coating formulation. These data therefore support the potential use of zein-starch mixed films for colonic targeting purposes.

KW - Zein

KW - Amylose

KW - Starch

KW - Colonic

KW - Drug delivery

KW - Fermentation studies

U2 - 10.1016/j.ijpharm.2018.12.021

DO - 10.1016/j.ijpharm.2018.12.021

M3 - Article

VL - 556

SP - 311

EP - 319

JO - International Journal of Pharmaceutics

T2 - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

ER -

ID: 147655661