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Hot melt extruded zein for controlled delivery of diclofenac sodium: effect of drug loading and medium composition

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  • Accepted_Manuscript

    Accepted author manuscript, 181 KB, PDF document

    Embargo ends: 3/06/21

DOI

Authors

  • Lorina Bisharat
  • Hatim Alkhatib
  • Amer Abdelhafez
  • Aya Barqawi
  • Ahmad Aljaberi
  • Sheng Qi
  • Alberto Berardi

Organisational units

Abstract

This study evaluates the potential use of zein as an excipient in hot-melt extrusion for controlled delivery of diclofenac sodium (DS). Mixtures of zein, polyethylene glycol and drug were hot melt extruded and cut into 2 mm extrudates. Extrudates were characterised using differential scanning calorimetry, X-ray powder diffraction and scanning electron microscopy. The drug in the extrudates was found to be in the non-crystalline state, independent of the drug loading. Moreover, the drug release from extrudates was investigated. The release was directly dependent on the drug loading: a controlled and nearly zero-order release was obtained at the lowest drug loading (12.5% w/w), whereas almost immediate release was achieved at higher drug loadings, i.e. 25% and 37.5%. The release was inversely dependent on the ionic strength of the medium. The influence of digestive enzymes on drug release was also studied. Pancreatin, but not pepsin, was found to have a significant influence on the drug release as well as on the microstructure of zein extrudates. These data therefore support the potential use of zein as excipient in hot melt extrusion for controlled release purposes.

Details

Original languageEnglish
Article number119503
JournalInternational Journal of Pharmaceutics
Volume585
Early online date3 Jun 2020
DOIs
Publication statusPublished - 30 Jul 2020
Peer-reviewedYes

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