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Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen

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Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen. / Lighten, Jackie (Lead Author); Papadopulos, Alexander S.T. ; Mohammed, Ryan S.; Ward, Ben J; Paterson, Ian; Baillie, Lyndsey; Bradbury, Ian R.; Hendry, Andrew P.; Bentzen, Paul; Van Oosterhout, Cock.

In: Nature Communications, Vol. 8, 1294, 03.11.2017.

Research output: Contribution to journalArticle

Harvard

Lighten, J, Papadopulos, AST, Mohammed, RS, Ward, BJ, Paterson, I, Baillie, L, Bradbury, IR, Hendry, AP, Bentzen, P & Van Oosterhout, C 2017, 'Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen', Nature Communications, vol. 8, 1294. https://doi.org/10.1038/s41467-017-01183-2

APA

Lighten, J., Papadopulos, A. S. T., Mohammed, R. S., Ward, B. J., Paterson, I., Baillie, L., Bradbury, I. R., Hendry, A. P., Bentzen, P., & Van Oosterhout, C. (2017). Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen. Nature Communications, 8, [1294]. https://doi.org/10.1038/s41467-017-01183-2

Vancouver

Lighten J, Papadopulos AST, Mohammed RS, Ward BJ, Paterson I, Baillie L et al. Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen. Nature Communications. 2017 Nov 3;8. 1294. https://doi.org/10.1038/s41467-017-01183-2

Author

Lighten, Jackie ; Papadopulos, Alexander S.T. ; Mohammed, Ryan S. ; Ward, Ben J ; Paterson, Ian ; Baillie, Lyndsey ; Bradbury, Ian R. ; Hendry, Andrew P. ; Bentzen, Paul ; Van Oosterhout, Cock. / Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen. In: Nature Communications. 2017 ; Vol. 8.

Bibtex- Download

@article{036b5812fef746d893263f75bed0dbf5,
title = "Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen",
abstract = "Red Queen host-parasite co-evolution can drive adaptations of immune-genes by positive selection that erodes genetic variation (Red Queen Arms Race), or result in a balanced polymorphism (Red Queen Dynamics) and the long-term preservation of genetic variation (trans-species polymorphism). These two Red Queen processes are opposite extremes of the co-evolutionary spectrum. Here we show that both Red Queen processes can operate simultaneously, analyzing the Major Histocompatibility Complex (MHC) in guppies (Poecilia reticulata and P. obscura), and swamp guppies (Micropoecilia picta). Sub-functionalization of MHC alleles into “supertypes” explains how polymorphisms persist during rapid host-parasite co-evolution. Simulations show the maintenance of supertypes as balanced polymorphisms, consistent with Red Queen Dynamics, whereas alleles within supertypes are subject to positive selection in a Red Queen Arms Race. Building on the Divergent Allele Advantage hypothesis, we show that functional aspects of allelic diversity help to elucidate the evolution of polymorphic genes involved in Red Queen co-evolution.",
author = "Jackie Lighten and Papadopulos, {Alexander S.T.} and Mohammed, {Ryan S.} and Ward, {Ben J} and Ian Paterson and Lyndsey Baillie and Bradbury, {Ian R.} and Hendry, {Andrew P.} and Paul Bentzen and {Van Oosterhout}, Cock",
year = "2017",
month = nov,
day = "3",
doi = "10.1038/s41467-017-01183-2",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen

AU - Lighten, Jackie

AU - Papadopulos, Alexander S.T.

AU - Mohammed, Ryan S.

AU - Ward, Ben J

AU - Paterson, Ian

AU - Baillie, Lyndsey

AU - Bradbury, Ian R.

AU - Hendry, Andrew P.

AU - Bentzen, Paul

AU - Van Oosterhout, Cock

PY - 2017/11/3

Y1 - 2017/11/3

N2 - Red Queen host-parasite co-evolution can drive adaptations of immune-genes by positive selection that erodes genetic variation (Red Queen Arms Race), or result in a balanced polymorphism (Red Queen Dynamics) and the long-term preservation of genetic variation (trans-species polymorphism). These two Red Queen processes are opposite extremes of the co-evolutionary spectrum. Here we show that both Red Queen processes can operate simultaneously, analyzing the Major Histocompatibility Complex (MHC) in guppies (Poecilia reticulata and P. obscura), and swamp guppies (Micropoecilia picta). Sub-functionalization of MHC alleles into “supertypes” explains how polymorphisms persist during rapid host-parasite co-evolution. Simulations show the maintenance of supertypes as balanced polymorphisms, consistent with Red Queen Dynamics, whereas alleles within supertypes are subject to positive selection in a Red Queen Arms Race. Building on the Divergent Allele Advantage hypothesis, we show that functional aspects of allelic diversity help to elucidate the evolution of polymorphic genes involved in Red Queen co-evolution.

AB - Red Queen host-parasite co-evolution can drive adaptations of immune-genes by positive selection that erodes genetic variation (Red Queen Arms Race), or result in a balanced polymorphism (Red Queen Dynamics) and the long-term preservation of genetic variation (trans-species polymorphism). These two Red Queen processes are opposite extremes of the co-evolutionary spectrum. Here we show that both Red Queen processes can operate simultaneously, analyzing the Major Histocompatibility Complex (MHC) in guppies (Poecilia reticulata and P. obscura), and swamp guppies (Micropoecilia picta). Sub-functionalization of MHC alleles into “supertypes” explains how polymorphisms persist during rapid host-parasite co-evolution. Simulations show the maintenance of supertypes as balanced polymorphisms, consistent with Red Queen Dynamics, whereas alleles within supertypes are subject to positive selection in a Red Queen Arms Race. Building on the Divergent Allele Advantage hypothesis, we show that functional aspects of allelic diversity help to elucidate the evolution of polymorphic genes involved in Red Queen co-evolution.

U2 - 10.1038/s41467-017-01183-2

DO - 10.1038/s41467-017-01183-2

M3 - Article

VL - 8

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 1294

ER -

ID: 118109348