HomePublications

Electron transfer from haem to the di-iron ferroxidase centre in bacterioferritin

Research output: Contribution to journalArticle

Open Access permissions

Open

Documents

DOI

Authors

Organisational units

Abstract

The iron redox cycle in ferritins is not completely understood. Bacterioferritins are distinct from other ferritins in that they contain haem groups. It is acknowledged that the two iron motifs in bacterioferritins, the di-nuclear ferroxidase centre and the haem B group, play key roles in two opposing processes, iron sequestration and iron mobilisation, respectively, and the two redox processes are independent. Herein, we show that in Escherichia coli bacterioferritin, there is an electron transfer pathway from the haem to the ferroxidase centre suggesting a new role(s) haem might play in bacterioferritins.

Details

Original languageEnglish
Pages (from-to)8376-8379
Number of pages4
JournalAngewandte Chemie International Edition
Volume60
Issue number15
Early online date18 Jan 2021
DOIs
Publication statusPublished - 6 Apr 2021
Peer-reviewedYes

Keywords

    Research areas

  • electron transfer, ferritins, ferroxidase centre, metalloproteins, stopped-flow spectrophotometry

View graph of relations

ID: 185945062