HomePublications

Cyclometallated Au(III) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies

Research output: Contribution to journalArticle

Documents

  • Accepted manuscript

    Accepted author manuscript, 1 MB, PDF-document

    Embargo ends: 18/09/19

DOI

Authors

Organisational units

Abstract

A series of cationic mixed cyclometallated (C^N)Au(III) dithiocarbamate complexes has been synthesized in good yields [HC^N = 2-(p-t-butylphenyl)pyridine]. The crystal structure of [(C^N)AuS2CNEt2]PF6 (3) has been determined. The cytotoxic properties of the new complexes have been evaluated in vitro against a panel of human cancer cell lines and healthy cells and compared with a neutral mixed (C^C)Au(III) dithiocarbamate complex (C^C = 4,4′-di-t-butylbiphenyl-2,2′-diyl). The complexes appeared to be susceptible to reduction by glutathione but were stable in the presence of N-acetyl cysteine. The potential mechanism of action of this class of compounds has been investigated by measuring the intracellular uptake of some selected complexes, by determining their interactions with higher order DNA structures, and by assessing the ability to inhibit thioredoxin reductase. The complexes proved unable to induce the formation of reactive oxygen species. The investigations add to the picture of the possible mode of action of this class of complexes.

Details

Original languageEnglish
Pages (from-to)1655-1666
JournalMetallomics
Volume10
Issue number11
Early online date18 Sep 2018
DOIs
StatePublished - 1 Nov 2018
Peer-reviewedYes

View graph of relations

ID: 142240975