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CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

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Abstract

In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.

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Original languageEnglish
Pages (from-to)12234-12237
JournalChemical Communications
Volume54
Issue number86
Early online date12 Oct 2018
DOIs
StatePublished - 7 Nov 2018
Peer-reviewedYes

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