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Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti-tumour investigations

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    Embargo ends: 3/09/19

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Abstract

(C^N) and (C^N^C) cyclometalated Au(III) represent a highly promising class of potential anticancer agents. We report here the synthesis of seven new cyclometalated Au(III) complexes with five of them bearing an acridine moiety attached via (N^O) or (N^N) chelates, acyclic amino carbenes (AAC) and N-heterocyclic carbenes (NHC). The antiproliferative properties of the different complexes were evaluated in vitro on a panel of cancer cells including leukaemia, lung and breast cancer cells. We observed a trend between the cytotoxicity and the intracellular gold uptake of some representative compounds of the series. Some of the acridine-decorated complexes were demonstrated to interact with ds-DNA using FRET-melting techniques.

Details

Original languageEnglish
Pages (from-to)13523-13534
JournalDalton Transactions
Volume47
Issue number38
Early online date3 Sep 2018
DOIs
StatePublished - 14 Oct 2018
Peer-reviewedYes

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