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A novel and highly stereoselective route for the synthesis of non-racemic 3-substituted isoindolin-1-one targets

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Abstract

A new, versatile and highly stereoselective approach for the synthesis of non-racemic 3-substituted isoindolin-1-ones is described from a readily available chiral template. The potential of this new protocol is demonstrated through the synthesis of an enantiomerically enriched 3-alkyl N-H isoindolin-1-one target with an e.e. of 98%.

Details

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalTetrahedron
Volume75
Issue number1
Early online date24 Nov 2018
DOIs
Publication statusPublished - 3 Jan 2019
Peer-reviewedYes

Keywords

    Research areas

  • Isoindolinone, N-Acyliminium, Stereoselective synthesis

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