1. 2020
  2. Published

    Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics

    Bhagwan, J. R., Mosqueira, D., Chairez-Cantu, K., Mannhardt, I., Bodbin, S. E., Bakar, M., Smith, J. G. W. & Denning, C., Aug 2020, In : Journal of Molecular and Cellular Cardiology. 145, p. 43-53 11 p.

    Research output: Contribution to journalArticle

  3. Published

    Mitochondrial DNA: Hotspot for potential gene modifiers regulating hypertrophic cardiomyopathy

    Kargaran, P. K., Evans, J. M., Bodbin, S. E., Smith, J. G. W., Nelson, T. J., Denning, C. & Mosqueira, D., 23 Jul 2020, In : Journal of Clinical Medicine. 9, 8

    Research output: Contribution to journalArticle

  4. E-pub ahead of print

    Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour

    Bhagwan, J. R., Collins, E., Mosqueira, D., Bakar, M., Johnson, B. B., Thompson, A., Smith, J. G. W. & Denning, C., 10 Jul 2020, In : F1000Research. 8, 1911.

    Research output: Contribution to journalArticle

  5. 2019
  6. Published

    ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection

    Mistry, J. J., Marlein, C. R., Moore, J. A., Hellmich, C., Wojtowicz, E. E., Smith, J. G. W., Macaulay, I., Sun, Y., Morfakis, A., Patterson, A., Horton, R. H., Divekar, D., Morris, C. J., Haestier, A., Di Palma, F., Beraza, N., Bowles, K. M. & Rushworth, S. A., 3 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24610-24619 10 p.

    Research output: Contribution to journalArticle

  7. Published

    Modeling Hypertrophic Cardiomyopathy: Mechanistic Insights and Pharmacological Intervention

    Mosqueira, D., Smith, J., Bhagwan, J. R. & Denning, C., 1 Sep 2019, In : Trends in Molecular Medicine. 25, 9, p. 775-790 16 p.

    Research output: Contribution to journalReview article

  8. 2018
  9. Published

    CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy

    Mosqueira, D., Mannhardt, I., Bhagwan, J. R., Lis-Slimak, K., Katili, P., Scott, E., Hassan, M., Prondzynski, M., Harmer, S. C., Tinker, A., Smith, J. G. W., Carrier, L., Williams, P. M., Gaffney, D., Eschenhagen, T., Hansen, A. & Denning, C., 14 Nov 2018, In : European Heart Journal. 39, 43, p. 3879-3892 14 p.

    Research output: Contribution to journalArticle

  10. Published

    Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits

    Smith, J. G. W., Owen, T., Bhagwan, J. R., Mosqueira, D., Scott, E., Mannhardt, I., Patel, A., Barriales-Villa, R., Monserrat, L., Hansen, A., Eschenhagen, T., Harding, S. E., Marston, S. & Denning, C., 13 Nov 2018, In : Stem Cell Reports. 11, 5, p. 1226-1243 18 p.

    Research output: Contribution to journalArticle

  11. Published

    The multifaceted roles of perlecan in fibrosis

    Lord, M. S., Tang, F., Rnjak-Kovacina, J., Smith, J., Melrose, J. & Whitelock, J. M., Aug 2018, In : Matrix Biology. 68-69, p. 150-166 17 p.

    Research output: Contribution to journalArticle

  12. Published

    Simplified footprint-free Cas9/CRISPR editing of cardiac-associated genes in human pluripotent stem cells

    Kondrashov, A., Hoang, M. D., Smith, J. G. W., Bhagwan, J. R., Duncan, G., Mosqueira, D., Munoz, M. B., Vo, N. T. N. & Denning, C., 12 Mar 2018, In : Stem Cells and Development. 27, 6, p. 391-404 14 p.

    Research output: Contribution to journalArticle

  13. 2016
  14. Published

    Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion

    Hammad, M., Rao, W., Smith, J. G. W., Anderson, D. G., Langer, R., Young, L. E., Barrett, D. A., Davies, M. C., Denning, C. & Alexander, M. R., 28 Jul 2016, In : Biomaterials Science. 4, 9, p. 1381-1391

    Research output: Contribution to journalArticle

  15. Published

    Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform

    Denning, C., Borgdorff, V., Crutchley, J., Firth, K. S. A., George, V., Kalra, S., Kondrashov, A., Hoang, M. D., Mosqueira, D., Patel, A., Prodanov, L., Rajamohan, D., Skarnes, W. C., Smith, J. G. W. & Young, L. E., Jul 2016, In : Biochimica et Biophysica Acta. 1863, 7, p. 1728-1748 21 p.

    Research output: Contribution to journalArticle

  16. 2015
  17. Published

    Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation

    Celiz, A. D., Smith, J. G. W., Patel, A. K., Hook, A. L., Rajamohan, D., George, V. T., Flatt, L., Patel, M. J., Epa, V. C., Singh, T., Langer, R., Anderson, D. G., Allen, N. D., Hay, D. C., Winkler, D. A., Barrett, D. A., Davies, M. C., Young, L. E., Denning, C. & Alexander, M. R., 15 Jul 2015, In : Advanced Materials. 27, 27, p. 4006-4012 7 p.

    Research output: Contribution to journalArticle

  18. Published

    Dental Pulp Cell Behavior in Biomimetic Environments

    Smith, J. G., Smith, A. J., Shelton, R. M. & Cooper, P. R., 2015, In : Journal of Dental Research. 94, 11, p. 1552-1559

    Research output: Contribution to journalArticle

  19. 2014
  20. Published

    Chemically diverse polymer microarrays and high throughput surface characterisation: a method for discovery of materials for stem cell culture

    Celiz, A. D., Smith, J. G. W., Patel, A. K., Langer, R., Anderson, D. G., Barrett, D. A., Young, L. E., Davies, M. C., Denning, C. & Alexander, M. R., 30 Nov 2014, In : Biomaterials Science. 2, 11, p. 1604-1611 8 p.

    Research output: Contribution to journalArticle

  21. Published

    Materials for stem cell factories of the future

    Celiz, A. D., Smith, J. G. W., Langer, R., Anderson, D. G., Winkler, D. A., Barrett, D. A., Davies, M. C., Young, L. E., Denning, C. & Alexander, M. R., 21 May 2014, In : Nature Materials. 13, p. 570-579 10 p.

    Research output: Contribution to journalArticle

  22. 2012
  23. Published

    Recruitment of dental pulp cells by dentine and pulp extracellular matrix components

    Smith, J. G., Smith, A. J., Shelton, R. M. & Cooper, P. R., 1 Nov 2012, In : Experimental Cell Research. 318, 18, p. 2397-2406 10 p.

    Research output: Contribution to journalArticle

ID: 147476246