1. 2021
  2. Published

    Allosteric site on SHIP2 identified through fluorescent ligand screening and crystallography: a potential new target for intervention

    Whitfield, H., Hemmings, A. M., Mills, S. J., Baker, K., White, G., Rushworth, S., Riley, A. M., Potter, B. V. L. & Brearley, C. A., 8 Apr 2021, In : Journal of Medicinal Chemistry. 64, 7, p. 3813–3826 14 p.

    Research output: Contribution to journalArticle

  3. 2020
  4. Published

    Bacterial iron detoxification at the molecular level

    Bradley, J. M., Svistunenko, D. A., Wilson, M. T., Hemmings, A. M., Moore, G. R. & Le Brun, N. E., 18 Dec 2020, In : The Journal of Biological Chemistry. 295, 51, p. 17602-17623 22 p.

    Research output: Contribution to journalReview article

  5. Published

    Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced fit structural mechanism

    Acquistapace, I. M., Zietek, M. A., Li, A. W. H., Salmon, M., Kuhn, I., Bedford, M. R., Brearley, C. A. & Hemmings, A. M., 18 Dec 2020, In : The Journal of Biological Chemistry. 295, 51, p. 17724-17737 14 p.

    Research output: Contribution to journalArticle

  6. Published
  7. Published

    Routes of iron entry into, and exit from, the catalytic ferroxidase sites of the prokaryotic ferritin SynFtn

    Bradley, J., Pullin, J., Moore, G., Svistunenko, D. A., Hemmings, A. & Le Brun, N., 7 Feb 2020, In : Dalton Transactions. 49, 5, p. 1545-1554 10 p.

    Research output: Contribution to journalArticle

  8. 2019
  9. Published

    Reaction of O2 with a di-iron protein generates a mixed valent Fe2+/Fe3+ center and peroxide

    Bradley, J. M., Svistunenko, D. A., Pullin, J., Hill, N., Stuart, R. K., Palenik, B., Wilson, M. T., Hemmings, A. M., Moore, G. R. & Le Brun, N. E., 5 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 116, 6, p. 2058-2067 10 p.

    Research output: Contribution to journalArticle

  10. 2018
  11. Published

    Analysis of two new Arabinosyltransferases belonging to the carbohydrate-active enzyme (CAZY) Glycosyl Transferase Family1 provides insights into disease resistance and sugar donor specificity

    Louveau, T., Orme, A., Pfalzgraf, H., Stephenson, M., Melton, R., Saalbach, G., Hemmings, A., Leveau, A., Rejzek, M., Vickerstaff, R., Langdon, T., Field, R. & Osbourn, A., 14 Dec 2018, In : Plant Cell. 30, 12, p. 3038-3057 20 p.

    Research output: Contribution to journalArticle

  12. Published

    Discovery of Small Molecule WWP2 Ubiquitin Ligase Inhibitors

    Watt, J., Hughes, G., Walpole, S., Monaco, S., Stephenson, G., Bulman Page, P., Hemmings, A., Angulo, J. & Chantry, A., 3 Dec 2018, In : Chemistry - A European Journal. 24, 67, p. 17677-17680 4 p.

    Research output: Contribution to journalArticle

  13. Published

    A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase

    Whitfield, H., Gilmartin, M., Baker, K., Riley, A. M., Godage, H. Y., Potter, B. VL., Hemmings, A. M. & Brearley, C. A., 11 Oct 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8838–8846

    Research output: Contribution to journalArticle

  14. 2016
  15. Published

    A conserved amino acid residue critical for product and substrate specificity in plant triterpene synthases

    Salmon, M., Thimmappa, R. B., Minto, R. E., Melton, R. E., Hughes, R. K., O'Maille, P. E., Hemmings, A. M. & Osbourn, A., Jul 2016, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 113, 30, p. E4407–E4414

    Research output: Contribution to journalArticle

  16. 2015
  17. Published

    Three aromatic residues are required for electron transfer during iron mineralization in Bacterioferritin

    Bradley, J. M., Svistunenko, D. A., Lawson, T. L., Hemmings, A. M., Moore, G. R. & Le Brun, N. E., 1 Dec 2015, In : Angewandte Chemie International Edition. 127, 49, p. 14976–14980

    Research output: Contribution to journalArticle

  18. 2014
  19. Published

    Structural and molecular insights into novel surface-exposed mucus adhesins from Lactobacillus reuteri human strains: A novel mucus adhesin from Lactobacillus reuteri

    Etzold, S., Mackenzie, D. A., Jeffers, F., Walshaw, J., Roos, S., Hemmings, A. M. & Juge, N., 1 May 2014, In : Molecular Microbiology. 92, 3, p. 543-556 14 p.

    Research output: Contribution to journalArticle

  20. Published

    Structural basis for adaptation of lactobacilli to gastrointestinal mucus

    Etzold, S., Kober, O. I., Mackenzie, D. A., Tailford, L. E., Gunning, A. P., Walshaw, J., Hemmings, A. M. & Juge, N., Mar 2014, In : Environmental Microbiology. 16, 3, p. 888-903 16 p.

    Research output: Contribution to journalArticle

  21. Published

    A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut

    Stentz, R., Osborne, S., Horn, N., Li, A., Hautefort, I., Bongaerts, R., Rouyer, M., Bailey, P., Shears, SB., Hemmings, A., Brearley, C. A. & Carding, S., 1 Feb 2014, In : Cell Reports. 6, 4, p. 646-656 11 p.

    Research output: Contribution to journalArticle

  22. 2013
  23. Published
  24. Published

    Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants

    Geisler, K., Hughes, R. K., Sainsbury, F., Lomonossoff, G. P., Rejzek, M., Fairhurst, S., Olsen, C-E., Motawia, M. S., Melton, R. E., Hemmings, A. M., Bak, S. & Osbourn, A., 27 Aug 2013, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 110, 35, p. E3360-E3367 8 p.

    Research output: Contribution to journalArticle

  25. Published

    Coiled-coil protein Scy is a key component of a multiprotein assembly controlling polarized growth in Streptomyces

    Holmes, N. A., Walshaw, J., Leggett, R. M., Thibessard, A., Dalton, K. A., Gillespie, M. D., Hemmings, A. M., Gust, B. & Kelemen, G. H., 2013, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 110, 5, p. 397-406 9 p.

    Research output: Contribution to journalArticle

  26. 2012
  27. Published

    Redox and Chemical Activities of the Hemes in the Sulfur Oxidation Pathway Enzyme SoxAX

    Bradley, JM., Marritt, SJ., Kihlken, MA., Haynes, K., Hemmings, AM., Berks, BC., Cheesman, MR. & Butt, JN., 2012, In : Journal of Biological Chemistry. 287, 48, p. 40350-40359 10 p.

    Research output: Contribution to journalArticle

  28. 2011
  29. Published
  30. 2010
  31. Published
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