1. 2021
  2. Published

    Allosteric site on SHIP2 identified through fluorescent ligand screening and crystallography: a potential new target for intervention

    Whitfield, H., Hemmings, A. M., Mills, S. J., Baker, K., White, G., Rushworth, S., Riley, A. M., Potter, B. V. L. & Brearley, C. A., 8 Apr 2021, In : Journal of Medicinal Chemistry. 64, 7, p. 3813–3826 14 p.

    Research output: Contribution to journalArticle

  3. 2020
  4. Published

    Bacterial iron detoxification at the molecular level

    Bradley, J. M., Svistunenko, D. A., Wilson, M. T., Hemmings, A. M., Moore, G. R. & Le Brun, N. E., 18 Dec 2020, In : The Journal of Biological Chemistry. 295, 51, p. 17602-17623 22 p.

    Research output: Contribution to journalReview article

  5. Published

    Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced fit structural mechanism

    Acquistapace, I. M., Zietek, M. A., Li, A. W. H., Salmon, M., Kuhn, I., Bedford, M. R., Brearley, C. A. & Hemmings, A. M., 18 Dec 2020, In : The Journal of Biological Chemistry. 295, 51, p. 17724-17737 14 p.

    Research output: Contribution to journalArticle

  6. Published
  7. Published

    Routes of iron entry into, and exit from, the catalytic ferroxidase sites of the prokaryotic ferritin SynFtn

    Bradley, J., Pullin, J., Moore, G., Svistunenko, D. A., Hemmings, A. & Le Brun, N., 7 Feb 2020, In : Dalton Transactions. 49, 5, p. 1545-1554 10 p.

    Research output: Contribution to journalArticle

  8. 2019
  9. Published

    Reaction of O2 with a di-iron protein generates a mixed valent Fe2+/Fe3+ center and peroxide

    Bradley, J. M., Svistunenko, D. A., Pullin, J., Hill, N., Stuart, R. K., Palenik, B., Wilson, M. T., Hemmings, A. M., Moore, G. R. & Le Brun, N. E., 5 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 116, 6, p. 2058-2067 10 p.

    Research output: Contribution to journalArticle

  10. 2018
  11. Published

    Analysis of two new Arabinosyltransferases belonging to the carbohydrate-active enzyme (CAZY) Glycosyl Transferase Family1 provides insights into disease resistance and sugar donor specificity

    Louveau, T., Orme, A., Pfalzgraf, H., Stephenson, M., Melton, R., Saalbach, G., Hemmings, A., Leveau, A., Rejzek, M., Vickerstaff, R., Langdon, T., Field, R. & Osbourn, A., 14 Dec 2018, In : Plant Cell. 30, 12, p. 3038-3057 20 p.

    Research output: Contribution to journalArticle

  12. Published

    Discovery of Small Molecule WWP2 Ubiquitin Ligase Inhibitors

    Watt, J., Hughes, G., Walpole, S., Monaco, S., Stephenson, G., Bulman Page, P., Hemmings, A., Angulo, J. & Chantry, A., 3 Dec 2018, In : Chemistry - A European Journal. 24, 67, p. 17677-17680 4 p.

    Research output: Contribution to journalArticle

  13. Published

    A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase

    Whitfield, H., Gilmartin, M., Baker, K., Riley, A. M., Godage, H. Y., Potter, B. VL., Hemmings, A. M. & Brearley, C. A., 11 Oct 2018, In : Journal of Medicinal Chemistry. 61, 19, p. 8838–8846

    Research output: Contribution to journalArticle

  14. 2016
  15. Published

    A conserved amino acid residue critical for product and substrate specificity in plant triterpene synthases

    Salmon, M., Thimmappa, R. B., Minto, R. E., Melton, R. E., Hughes, R. K., O'Maille, P. E., Hemmings, A. M. & Osbourn, A., Jul 2016, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 113, 30, p. E4407–E4414

    Research output: Contribution to journalArticle

  16. 2015
  17. Published

    Three aromatic residues are required for electron transfer during iron mineralization in Bacterioferritin

    Bradley, J. M., Svistunenko, D. A., Lawson, T. L., Hemmings, A. M., Moore, G. R. & Le Brun, N. E., 1 Dec 2015, In : Angewandte Chemie International Edition. 127, 49, p. 14976–14980

    Research output: Contribution to journalArticle

  18. 2014
  19. Published

    Structural and molecular insights into novel surface-exposed mucus adhesins from Lactobacillus reuteri human strains: A novel mucus adhesin from Lactobacillus reuteri

    Etzold, S., Mackenzie, D. A., Jeffers, F., Walshaw, J., Roos, S., Hemmings, A. M. & Juge, N., 1 May 2014, In : Molecular Microbiology. 92, 3, p. 543-556 14 p.

    Research output: Contribution to journalArticle

  20. Published

    Structural basis for adaptation of lactobacilli to gastrointestinal mucus

    Etzold, S., Kober, O. I., Mackenzie, D. A., Tailford, L. E., Gunning, A. P., Walshaw, J., Hemmings, A. M. & Juge, N., Mar 2014, In : Environmental Microbiology. 16, 3, p. 888-903 16 p.

    Research output: Contribution to journalArticle

  21. Published

    A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut

    Stentz, R., Osborne, S., Horn, N., Li, A., Hautefort, I., Bongaerts, R., Rouyer, M., Bailey, P., Shears, SB., Hemmings, A., Brearley, C. A. & Carding, S., 1 Feb 2014, In : Cell Reports. 6, 4, p. 646-656 11 p.

    Research output: Contribution to journalArticle

  22. 2013
  23. Published
  24. Published

    Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants

    Geisler, K., Hughes, R. K., Sainsbury, F., Lomonossoff, G. P., Rejzek, M., Fairhurst, S., Olsen, C-E., Motawia, M. S., Melton, R. E., Hemmings, A. M., Bak, S. & Osbourn, A., 27 Aug 2013, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 110, 35, p. E3360-E3367 8 p.

    Research output: Contribution to journalArticle

  25. Published

    Coiled-coil protein Scy is a key component of a multiprotein assembly controlling polarized growth in Streptomyces

    Holmes, N. A., Walshaw, J., Leggett, R. M., Thibessard, A., Dalton, K. A., Gillespie, M. D., Hemmings, A. M., Gust, B. & Kelemen, G. H., 2013, In : Proceedings of the National Academy of Sciences of the United States of America (PNAS). 110, 5, p. 397-406 9 p.

    Research output: Contribution to journalArticle

  26. 2012
  27. Published

    Redox and Chemical Activities of the Hemes in the Sulfur Oxidation Pathway Enzyme SoxAX

    Bradley, JM., Marritt, SJ., Kihlken, MA., Haynes, K., Hemmings, AM., Berks, BC., Cheesman, MR. & Butt, JN., 2012, In : Journal of Biological Chemistry. 287, 48, p. 40350-40359 10 p.

    Research output: Contribution to journalArticle

  28. 2011
  29. Published
  30. 2010
  31. Published
  32. 2009
  33. Published

    A Tetranuclear Cu(I) Cluster in the Metallochaperone Protein CopZ

    Hearnshaw, S., West, C., Singleton, C., Zhou, L., Kihlken, M. A., Strange, R. W., Le Brun, N. E. & Hemmings, A. M., 11 Sep 2009, In : Biochemistry. 48, 40, p. 9324-9326 3 p.

    Research output: Contribution to journalArticle

  34. Published

    Crystal Structure of a Mucus-binding Protein Repeat Reveals an Unexpected Functional Immunoglobulin Binding Activity

    MacKenzie, D. A., Tailford, L. E., Hemmings, A. M. & Juge, N., 2009, In : Journal of Biological Chemistry. 284, 47, p. 32444-32453 10 p.

    Research output: Contribution to journalArticle

  35. Published

    Mechanistic insights into Cu(I) cluster transfer between the chaperone CopZ and its cognate Cu(I)-transporting P-type ATPase, CopA

    Singleton, C., Hearnshaw, S., Zhou, L., Le Brun, N. & Hemmings, A., 2009, In : Biochemical Journal. 424, 3, p. 347-356 10 p.

    Research output: Contribution to journalArticle

  36. 2008
  37. Published

    Solanum tuberosum inositol phosphate kinase (StlTPK1) displaying inositol phosphate-inositol phosphate and inositol phosphate-ADP phosphotransferase activities

    Caddick, S. E. K., Harrison, C. J., Stavridou, I., Mitchell, J. L., Hemmings, A. M. & Brearley, C. A., 28 May 2008, In : FEBS Letters. 582, 12, p. 1731-1737 7 p.

    Research output: Contribution to journalArticle

  38. Published

    Role of a conserved gluatmine residue in tuning the catalytic activity of Escherichia coli cytochrome c nitrite reductase

    Clarke, T. A., Kemp, G. L., Van Wonderen, J. H., Doyle, R-M. A. S., Cole, J. A., Tovell, N., Cheesman, M. R., Butt, J. N., Richardson, D. J. & Hemmings, A. M., 1 Mar 2008, In : Biochemistry. 47, 12, p. 3789-3799 11 p.

    Research output: Contribution to journalArticle

  39. Published

    Escherichia coli cytochrome c nitrite reductase NrfA

    Clarke, T. A., Mills, P. C., Poock, S. R., Butt, J. N., Cheesman, M. R., Cole, J. A., Hinton, J. C. D., Hemmings, A. M., Kemp, G., Söderberg, C. A. G., Spiro, S., Van Wonderen, J. & Richardson, D. J., 2008, In : Methods in Enzymology. 437, p. 63-77 15 p.

    Research output: Contribution to journalArticle

  40. 2007
  41. Published
  42. Published

    Spectropotentiometric and structural analysis of the periplasmic nitrate reductase from Escherichia coli

    Jepson, B. J. N., Mohan, S., Clarke, T. A., Gates, A. J., Cole, J. A., Butler, C. S., Butt, J. N., Hemmings, A. M. & Richardson, D. J., 2 Mar 2007, In : Journal of Biological Chemistry. 282, p. 6425-6437 13 p.

    Research output: Contribution to journalArticle

  43. Published

    The SoxYZ complex carries sulfur cycle intermediates on a peptide swinging arm

    Sauvé, V., Bruno, S., Berks, B. C. & Hemmings, A. M., 2007, In : Journal of Biological Chemistry. 282, p. 23194-23204 11 p.

    Research output: Contribution to journalArticle

  44. 2006
  45. Published

    MLEM deconvolution of protein X-ray diffraction images based on a multiple-PSF model

    Zhu, D., Razaz, M. & Hemmings, A., 30 May 2006, In : IEEE Transactions on Nanobioscience. 5, 2, p. 95-102 8 p.

    Research output: Contribution to journalArticle

  46. Published

    In vitro characterization of a bacterial manganese uptake regulator of the fur superfamily

    Bellini, P. & Hemmings, A. M., 3 Feb 2006, In : Biochemistry. 45, 8, p. 2686-2698 13 p.

    Research output: Contribution to journalArticle

  47. Published

    A different function for a member of an ancient and highly conserved cytochrome P450 family: From essential sterols to plant defense

    Qi, X., Bakht, S., Qin, B., Leggett, M., Hemmings, A., Mellon, F., Eagles, J., Werck-Reichhart, D., Schaller, H., Lesot, A., Melton, R. & Osbourn, A., 2006, In : Proceedings of the National Academy of Sciences USA. 103, 49, p. 18848-18853 6 p.

    Research output: Contribution to journalArticle

  48. Published
  49. Published

    In vitro characterization of the cysteine-rich capping domains in a plant leucine rich repeat protein

    Kolade, O. O., Bamford, V. A., Anton, G. A., Jones, J. D. G., Vera, P. & Hemmings, A. M., 2006, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1764, 6, p. 1043-1053 11 p.

    Research output: Contribution to journalArticle

  50. 2005
  51. Published

    Analysis of ligation and DNA binding by Escherichia coli DNA ligase (LigA).

    Wilkinson, A., Smith, A., Bullard, D., Lavesa-Curto, M., Sayer, H., Bonner, A., Hemmings, A. & Bowater, R., 20 May 2005, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1749, 1, p. 113-122 10 p.

    Research output: Contribution to journalArticle

  52. Published

    Cytochrome c nitrite reductase: from structural to physicochemical analysis

    Burlat, B., Gwyer, JD., Poock, S., Clarke, TA., Cole, JA., Hemmings, AM., Cheesman, MR., Butt, JN. & Richardson, DJ., 2005, In : Biochemical Society Transactions. 33, 1, p. 137-140 4 p.

    Research output: Contribution to journalArticle

  53. Published

    Helical peptide found in the channel of the outer membrance protein TolC

    Fanutti, C., Coussons, PJ. & Hemmings, AM., 2005.

    Research output: Contribution to conferenceOther

  54. 2004
  55. Published

    Characterization of a temperature-sensitive DNA ligase from Escherichia coli

    Lavesa-Curto, M., Sayer, H., Bullard, D., MacDonald, A., Wilkinson, A., Smith, A., Bowater, L., Hemmings, A. & Bowater, R. P., Dec 2004, In : Microbiology. 150, p. 4171-4180 10 p.

    Research output: Contribution to journalArticle

  56. Published
  57. Published

    Multiple point spread function modeling for deconvolution of 3D X-ray diffraction data

    Zhu, D., Razaz, M., Hemmings, A. & Wang, B., 2004, In : Journal of X-Ray Science & Technology. 12, p. 179-194 16 p.

    Research output: Contribution to journalArticle

  58. Published

    Multi-PSF modelling for X-ray diffraction pattern reconstruction

    Zhu, D., Razaz, M., Hemmings, A. & Wang, B., 2004, p. 529-532. 4 p.

    Research output: Contribution to conferencePaper

  59. Published

    Purification, crystallization and preliminary X-ray diffraction analysis of a fungal saponin-detoxifying enzyme

    Bamford, V. A., Kolade, O. O., Osbourn, A. E. & Hemmings, A. M., 2004, In : Acta Crystallographica D. 60, p. 1331-1333 3 p.

    Research output: Contribution to journalArticle

  60. 2003
  61. Published

    Fur is not the global regulator of iron uptake genes in Rhizobium leguminosarum

    Wexler, M., Todd, J. D., Kolade, O., Bellini, D., Hemmings, A. M., Sawers, G. & Johnston, A. W. B., 2003, In : Microbiology. 149, p. 1357-1365 9 p.

    Research output: Contribution to journalArticle

  62. 2002
  63. Published

    Structure and Spectroscopy of the Periplasmic Cytochrome c Nitrite Reductase from Escherichia coli

    Bamford, V. A., Angove, H. C., Seward, H. E., Thomson, A. J., Cole, J. A., Butt, J., Hemmings, A. & Richardson, D., 5 Feb 2002, In : Biochemistry. 41, 9, p. 2921-2931 11 p.

    Research output: Contribution to journalArticle

  64. Published

    Multistep binding of transition metals to the H-N-H endonuclease toxin colicin E9

    Keeble, A. H., Hemmings, A. M., James, R., Moore, G. R. & Kleanthous, C., 2002, In : Biochemistry. 41, p. 10234-10244 11 p.

    Research output: Contribution to journalArticle

  65. Published

    Novel domain packing in the crystal structure of a thiosulphate-oxidizing enzyme.

    Bamford, V. A., Berks, B. C. & Hemmings, A. M., 2002, In : Biochemical Society Transactions. 30, p. 638-642 5 p.

    Research output: Contribution to journalArticle

  66. Published

    Structural aspects of the inhibition of Dnase and rRNase colicins by their immunity proteins

    Kolade, O. O., Carr, S. B., Kühlmann, U. C., Pommer, A., Kleanthous, C., Bouchcinsky, C. A. & Hemmings, A. M., 2002, In : Biochimie. 84, 5-6, p. 439-446 8 p.

    Research output: Contribution to journalArticle

  67. Published

    Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme

    Bamford, V. A., Bruno, S., Rasmussen, T., Appia-Ayme, C., Cheesman, M. R., Berks, B. C. & Hemmings, A. M., 2002, In : The EMBO Journal. 21, p. 5599-5610 12 p.

    Research output: Contribution to journalArticle

  68. Published

    Structural dynamics of the membrane translocation domain of colicin E9 and its interaction with TolB

    Collins, E. S., Whittaker, S. B-M., Tozawa, K., MacDonald, C. J., Boetzel, R., Penfold, C. N., Reilly, A., Clayden, N. J., Osborne, M. J., Hemmings, A. M., Kleanthous, C., James, R. & Moore, G. R., 2002, In : Journal of Molecular Biology. 318, p. 787-804 18 p.

    Research output: Contribution to journalArticle

  69. Published

    Structural studies of the Fur protein from Rhizobium leguminosarum.

    Kolade, O. O., Bellini, P., Wexler, M., Johnston, A. W. B., Grossmann, J. G. & Hemmings, A. M., 2002, In : Biochemical Society Transactions. 30, p. 771-774 4 p.

    Research output: Contribution to journalArticle

  70. 2001
  71. Published

    Mechanism and cleavage specificity of the H-N-H endonuclease colicin E9

    Pommer, A. J., Cal, S., Keeble, A. H., Walker, D., Evans, S. J., Kuhlmann, U. C., Cooper, A., Connolly, B. A., Hemmings, A., Moore, G., James, R. & Kleanthous, C., 2001, In : Journal of Molecular Biology. 314, 4, p. 735-749 15 p.

    Research output: Contribution to journalArticle

ID: 12460