Biography

ResearcherID

Jesus Angulo Profile ResearcherID: H-1253-2011

Google Scholar Citations

http://scholar.google.com/citations?user=Fmfn4-8AAAAJ

PhD Positions

Click here for current PhD opportunities in PHA. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Postdoctoral Positions

I am always open to discuss possibilities for postdoctoral work and collaborations.

Jesús studied Chemistry at the University of Seville (Spain). He then obtained his doctorate working at the Instituto de Investigaciones Químicas (IIQ) of the Consejo Superior de Investigaciones Cientificas and University of Seville, in 2002, in the “Carbohydrate Group” led by Prof. Manuel Martín-Lomas, under the supervision of Dr. Pedro Nieto. His thesis was based on the study of the 3D structures and dynamics of oligosaccharides models of glycosaminoglycans (GAGs) by NMR spectroscopy and molecular dynamics simulations. He then moved to Germany for a three-year postdoctoral stay in the research group of Prof. Thomas Peters at the University of Lübeck, where he got a Marie Curie Intra-European Individual Fellwoship to specialize in ligand-based NMR spectroscopy for protein-ligand interactions, with a focus on molecular recognition of substrates by the human blood group B galactosyltransferase (GTB). After that, he joined back the Carbohydrate Group of IIQ (Seville) in 2006 as a "Juan de la Cierva" postdoctoral scientist, and from 2008 to 2013 he worked at the “Glycosystems Laboratory” of the IIQ as a senior scientist, with a prestigious "Ramón y Cajal" award, on NMR and computational chemistry for the study of the interactions of glycosaminoglycans, glycomimetics, and gold glyconanoparticles with protein receptors of relevance in infection processes (anti-HIV-1 2G12 antibody, DC-SIGN and langerin lectins). From September 2012 to September 2013 he is the Secretary of the NMR Group of the Spanish Royal Society of Chemistry. Jesus joined the School of Pharmacy of the University of East Anglia in August 2013 as a Research Fellow was promoted to Lecturer in August 2016 and is currently Senior Lecturer in NMR Spectroscopy since August 2017 within the research area of Drug Delivery and Pharmaceutical Materials.

Jesús main research interests focus on the structural and dynamics characterization of biologically active molecules, with a particular focus on glycans, and the molecular recognition of ligands by receptors of both kinds, natural (proteins, nucleic acids,…), or non-natural (materials), heavily relying on NMR spectroscopy and computational techniques.

Research areas

- Structural characterization of Ligand-Receptor interactions by NMR Spectroscopy

  • Carbohydrate-Protein interactions. Carbohydrates in drug-delivery.
  • Drug-carrier interactions
  • Ligand-based NMR for “in-cell” ligand-protein interactions

- Structure and dynamics of biologically active small/medium-sized molecules

Selected publications

Differential Epitope Mapping by STD NMR Spectroscopy To Reveal the Nature of Protein–Ligand Contacts
S.Monaco, L.E. Tailford, N. Juge, J. Angulo
Angew. Chem. Int. Ed., 2017, 56, 15289-15293
DOI: 10.1002/chem.201600114

Unveiling the "Three Finger Pharmacophore" required for p53-MDM2 Inhibition by Saturation Transfer Difference NMR Initial Growth Rates Approach
J. Angulo, S. Goffin, D. Gandhi, M. Searcey, L. Howell
Chem.Eur.J., 2016, 22, 5858-5862
DOI: 10.1002/chem.201600114

Kinetics of Intramolecular Chemical Exchange by Initial Growth Rates of Spin Saturation Transfer Difference Experiments (SSTD NMR)
M.T. Quiros, J. Angulo, and M.P. Muñoz
Chem. Comm., 2015, 51, 10222-10225
DOI: 10.1039/C5CC02941D

Langerin-Heparin Interaction: Two Binding Sites for Small and Large Ligands as revealed by a combination of NMR Spectroscopy and Cross-Linking Mapping Experiments
J.C. Munoz-Garcia, E. Chabrol, R.R. Vives, A. Thomas, J.L. de Paz, J. Rojo, A. Imberty, F. Fieschi, P.M. Nieto, and  J. Angulo
J. Am. Chem. Soc., 2015, 137 (12), 4100-4110
DOI:10.1021/ja511529x

Structure of a Glycomimetic Ligand in the Carbohydrate Recognition Domain of C-type Lectin DC-SIGN. Structural Requirements for Selectivity and Ligand Design
Thepaut, M., C. Guzzi, I. Sutkeviciute, S. Sattin, R. Ribeiro-Viana, N. Varga, E. Chabrol, J. Rojo, A. Bernardi, J. Angulo, P. M. Nieto and F. Fieschi
J. Am. Chem. Soc., 2013, 135(7), 2518-2529
DOI: 10.1021/ja3053305

sp2-Iminosugar O-, S-, and N-Glycosides as Conformational Mimics of a-Linked Disaccharides; Implications for Glycosidase Inhibition
Sanchez-Fernandez, E. M., R. Risquez-Cuadro, C. Ortiz Mellet, J. M. Garcia Fernandez, P. M. Nieto and J. Angulo
Chem. Eur. J., 2012, 18(27), 8527-8539
DOI: 10.1002/chem.201200279

A Solution NMR Study of the Interactions of Oligomannosides and the Anti-HIV-1 2G12 Antibody Reveals Distinct Binding Modes for Branched Ligands
Enriquez-Navas, P. M., M. Marradi, D. Padro, J. Angulo and S. Penades
Chem. Eur. J., 2011, 17(5), 1547-1560
DOI: 10.1002/chem.201002519

Ligand-Receptor Binding Affinities from Saturation Transfer Difference (STD) NMR Spectroscopy: The Binding Isotherm of STD Initial Growth Rates
Angulo, J., P. M. Enriquez-Navas and P. M. Nieto
Chem. Eur. J., 2010, 16(26), 7803-7812
DOI: 10.1002/chem.200903528
(Highlighted on the Journal Issue as a Very Important “VIP” paper)

 

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