Biography

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Fraser obtained a BSc in Chemistry from the University of Sheffield in 1987 and a Dr. rer. nat. from the Department of Chemistry at the Free University of Berlin (Germany) in 1993. He pursued post-doctoral research at the Technical University Berlin (Germany) (1993-1995), the Commissariat de l’Energie Atomique, Saclay, France (1995-1998) and the Johann Wolfgang Goethe-University Frankfurt (Germany) (1998-2006).

Fraser is currently a Reader in the School of Chemistry at the University of East Anglia, Norwich where he joined the faculty in 2007. To coincide with his appointment Fraser has won a Royal Society Wolfson Research Merit Award. He leads biological EPR research in the Henry Welcome Laboratory.

His present research aims to elucidate structure / function / dynamics relationships in biomacromolecules and macromolecular complexes. Particular emphasis being on the application, and expansion, of electron paramagnetic resonance methods to study membrane proteins.

Selected publications
Refined Distances Between Paramagnetic Centers of a Multi-Copper Nitrite Reductase Determined by Pulsed EPR (iDEER) Spectroscopy
J. van Wonderen, D. N. Kostrz, C. Dennison, F. MacMillan,*
Angewandte Chemie Int. Ed. 52, 7, 1990–1993, 2013
DOI: 10.1002/anie.201208166

Interconversions of P and F Intermediates of Cytochrome c Oxidase from Paracoccus denitrificans.
I. van der Hocht, J. van Wonderen, F. Hilbers, H. Angerer, F. MacMillan, & H. Michel
Proc. Natl. Acad. Sci. USA, 108 10, 3964-3969, 2011
DOI: 10.1073/pnas.1100950108

Elucidating Mechanisms in Haem Copper Oxidases: The High Affinity QH Binding Site in Quinol Oxidase as studied by DONUT-HYSCORE Spectroscopy and Density Functional Theory.
F. MacMillan, S. Kacprzak, P. Hellwig, S. Grimaldi, H. Michel & M. Kaupp
Faraday Discussions, 148, 315-345 2011
DOI: 10.1039/c005149g

Resolving EPR spectra in the Cytochrome bc1 complex from Saccharomyces cerevisiae.
F. MacMillan, C. Lange, M. Bawn, & C. Hunte
Applied Magnetic Resonance 37, 685-692 2010
DOI: 10.1007/s00723-009-0077-4

Surface Chemistry, Reactivity, and Pore Structure of Porous Silicon Oxidized by Various Methods
J. Riikonen, M. Salomäki, J. van Wonderen, M. Kemell, W. Xu, O. Korhonen, M. Ritala, F. MacMillan, J. Salonen, and V.-P. Lehto
Langmuir, 28 (28), pp 10573–10583, 2012
DOI: 10.1021/la301642w

Applications of high resolution EPR to iron-sulphur proteins in electron transfer chains
in Metals in Biology: Applications of High Resolution EPR to Metalloenzymes
.
R. Cammack & F. MacMillan (Editors, Graeme R. Hanson and Lawrence J. Berliner),
Biological Magnetic Resonance Vol. 29 Springer Publishers, New York, 11-44 2010
DOI: 10.1007/978-1-4419-1139-1
 

Career

  • 2007 –  present: Reader in Chemistry in the School of Chemistry and Director of the Henry Wellcome Unit for Biological EPR, UEA
  • 2007 – 2012: Wolfson Research Merit Award of The Royal Society
  • 1998 – 2006: Independent/Junior Group Leader Fachbereich Chemie, Biochemie & Pharmazie, J. W. Goethe Universität, Frankfurt, Germany
  • 1995 – 1998: Marie-Curie Stipendiat (of the EU)  at the CEA Saclay, Séction de Bioénergétique, CEA Saclay, Gif-sur-Yvette, France 1993 – 1995    Post-Doc in the Max-Volmer Institut of the Technische Universität Berlin, Germany
  • 1988 – 1993: Dr. rer. nat. in the Institut für Organische Chemie of the Freie Universität Berlin, Germany
  • 1984 – 1987: B.Sc. Sp. Hons. in Pure and Applied Chemistry at the University of Sheffield, UK

 

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