Biography

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Chris Hamilton graduated from the University of Liverpool (1994) and got his PhD (1997) from the University of Exeter working with Prof. Stan Roberts on the synthesis of biologically stable nor-carbovir triphosphate analogues as inhibitors of HIV reverse transcriptase. This was followed by postdoctoral appointments with Prof David Gani working on ‘protein phosphatase assay development’ (St Andrews, 1998) and Dr Ian Eggleston/Prof Alan Fairlamb ‘synthesis of lunaria alkaloids & mechanistic studies as trypanothione reductase inhibitors’, (Dundee, 1999-2000). He then worked at UEA with Prof. Rob Field, first as a postdoctoral researcher (Studying Bordetella pertussis lipopolysaccharide biosynthesis, 2001) and then as a fixed term lecturer (2002). Shortly after receiving a Wellcome Trust SHOWCASE award, he took up post as Lecturer in Organic Chemistry at Queen’s University Belfast in late-2003. He returned to UEA (late 2007). His research interests reside at the Chemistry/Biology interface. This is exemplified by the cross section of research group members, which includes researchers with expertise in synthetic chemistry, biochemistry, microbiology and plant biology. Current research interests are focussed in the following areas:-

  • Chemical and biochemical functions of low molecular weight thiols in Gram positive bacteria.
  • Redox mechanisms of bioactive organosulfur metabolites from garlic
  • Mechanistic enzymology

Dr Hamilton is part of the Medicinal Chemistry Group.

Selected publications

Mechanistic studies of FosB: a divalent metal-dependent bacillithiol-S-transferase that mediates fosfomycin resistance in Staphylococcus aureus
A.A. Roberts, S.V. Sharma, A.W. Strankman, S.R. Duran, M. Rawat, C.J. Hamilton*
Biochem. J. 2013, 451, 69-79
DOI: 10.1042/BJ20121541

Distribution and infection related functions of bacillithiol in Staphylococcus aureus
D. Pöther, P. Gierok, M. Harms3, J. Mostertz, F. Hochgräfe, H. Antelmann, C.J. Hamilton, I. Borovok, M. Lalk, Y. Aharonowitz, M. Hecker*
Int. J. Med. Microbiol. 2012 (in press)
DOI: 10.1016/j.ijmm.2013.01.003

Chemical and chemoenzymatic syntheses of bacillithiol: A unique low molecular-weight thiol amongst low G + C Gram-positive bacteria.
Sunil V. Sharma, Vishnu K. Jothivasan, Gerald L. Newton, Heather Upton, Judy I. Wakabayashi, Melissa G. Kane, Alexandra A. Roberts, Mamta Rawat, James J. La Clair, Chris J. Hamilton
Angewandte Chemie International Edition, 2011, 50, 31, 7101–7104
DOI: 10.1002/anie.201100196

Bacillithiol is an antioxidant thiol produced in Bacilli.
G. L. Newton, M. Rawat, J. J. La Clair, V. K. Jothivasan, T. Budiarto, C. J. Hamilton, Al Claiborne, J. D. Helmann, R. C. Fahey*,
Nat. Chem. Biol. 2009, 625-627.
DOI:10.1038/nchembio.189

Mycothiol disulfide reductase:- A continuous assay for slow time-dependent inhibitors.
C. J. Hamilton,* R. M. J. Finlay, M. J.G. Stewart, A. Bonner.
Analytical Biochem., 2009, 388, 91-96.
DOI:10.1016/j.ab.2009.02.015

Nucloside triphosphate mimicry:- A sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase.
A.S. Rowan, N.I. Nicely, N. Cochrane, W.A. Wlassoff, A. Claiborne, C.J. Hamilton.
Org. Biomol. Chem. 2009, 7, 4029-4037.
DOI: 10.1039/b909729e

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