Anja Mueller

Biography

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Anja obtained a degree in Biology at the University of the Saar in Saarbruecken, Germany in 1995. She then went on to undertake a PhD at the Institute of Virology at the University Hospital in Homburg/Saar, Germany. After finishing her PhD she carried out postdoctoral research with Philip Strange at the University of Reading (1999-2002) and then joined the group of James Pease at Imperial College London (2003-2004). She joined UEA in August 2004 as a Lecturer in Molecular Pharmacology and was promoted to Senior Lecturer in 2009.

Anja's primary research interest is the investigation of cell signalling mechanisms of chemokine receptors which are a subgroup of G-protein-coupled receptors. She is interested in how the expression of these receptors is regulated on the cell surface and how they activate heterotrimeric G-proteins and other intracellular signalling pathways to induce cell migration.

Selected Publications

Differential regulation of chemotaxis: Role of Gβγ in chemokine receptor-induced cell migration. 
Kerr JS, Jacques RO, Moyano Cardaba C, Tse T, Sexton D, Mueller A Cell Signal. 2013, April; 25(4): 729–735,
DOI:10.1016/j.cellsig.2012.12.015.

Cellular uptake studies of two hexanuclear, carboxylate bridged, zinc ring structures using fluorescence microscopy
Redshaw C, Elsegood MR, Frese JW, Ashby S, Chao Y, Mueller A.
Chem Commun (Camb). 2012 Jul 7;48(53):6627-9. Epub 2012 May 1
DOI: 10.1039/C2CC32060F

Stable and Sensitive Probes for Lysosomes: Cell-Penetrating Fluorescent Calix[4]arenes Accumulate in Acidic Vesicles.
Mueller, A., Lalor, R., Moyano Cardaba, C, Matthews, S.E.
Cytometry A. 2011 Feb;79(2):126-36.
DOI: 10.1002/cyto.a.21002. Epub 2010 Dec 23.

Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells.
Moyano Cardaba, C, Mueller A
Biochem Pharmacol, 2009; 78; 974-982,
DOI:10.1016/j.bcp.2009.06.003

CCR5 internalisation and signalling have different dependence on membrane lipid raft integrity.
Moyano Cardaba, C, Kerr JS, Mueller A
Cell Signalling, 2008; 20; 1687-1694
DOI: 10.1016/j.cellsig.2008.05.014

CXCL4-induced migration of activated T-lymphocytes is mediated by the chemokine receptor CXCR3.
Mueller A, Meiser A, McDonagh EM, Fox JM, Petit S, Xanthou G, Williams TJ, Pease JE.
J Leukoc Biol. 2008 Jan 3; [Epub ahead of print]
DOI: 10.1189/jlb.1006645

The CXC chemokine MIG/CXCL9 is important in innate immunity against Streptococcus pyogenes.
Egesten A, Eliasson M, Johansson HM, Olin AI, Morgelin M, Mueller A, Pease JE, Frick IM, Bjorck L.
Journal of Infectious Diseases, 2007 195, 684-693
DOI:10.1086/510857
 

Career

• 1999-2002 Postdoc, School of Animal and Microbial Sciences, University of Reading
• 2002-2004 Postodc, Department of Leukocyte Biology, Imperial College London
• 2004-2009 Lectuer in Molecular Pharmacology, University of East Anglia, Norwich
• 2009 - Senior Lecturer in Molecular Pharmacology, University of East Anglia, Norwich

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