Anja Mueller

Biography

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Anja obtained a degree in Biology at the University of the Saar in Saarbruecken, Germany in 1995. She then went on to undertake a PhD at the Institute of Virology at the University Hospital in Homburg/Saar, Germany. After finishing her PhD she carried out postdoctoral research with Philip Strange at the University of Reading (1999-2002) and then joined the group of James Pease at Imperial College London (2003-2004). She joined UEA in August 2004 as a Lecturer in Molecular Pharmacology and was promoted to Senior Lecturer in 2009.

Anja's primary research interest is the investigation of cell signalling mechanisms of chemokine receptors which are a subgroup of G-protein-coupled receptors. She is interested in how the expression of these receptors is regulated on the cell surface and how they activate heterotrimeric G-proteins and other intracellular signalling pathways to induce cell migration.

Selected Publications

The Role of PKC and PKD in CXCL12 directed Prostate Cancer Migration.

Hamshaw I, Ajdarirad M, Mueller A (2019)  Biochem Biophys Res Commun. 2019 Oct 29;519(1):86-92. doi: 10.1016/j.bbrc.2019.08.134.

CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration.

Fox JM, Kausar F, Day A, Osborne M, Hussain K, Mueller A, Lin J, Tsuchiya T, Kanegasaki S, Pease JE (2018)  Scientific Reports (2018) 8:9466. DOI:10.1038/s41598-018-27710-9

Cell migration towards CXCL12 in leukemic cells compared to breast cancer cells.

Mills SC, Goh PH, Kudatsih J, Ncube S, Gurung R, Maxwell W and Mueller A (2016)  Cell Signal. 2016 Jan 21;28(4):316-324. doi: 10.1016/j.cellsig.2016.01.006.

Cellular uptake studies of two hexanuclear, carboxylate bridged, zinc ring structures using fluorescence microscopy

Redshaw C, Elsegood MR, Frese JW, Ashby S, Chao Y, Mueller A.
Chem Commun (Camb). 2012 Jul 7;48(53):6627-9. Epub 2012 May 1
DOI: 10.1039/C2CC32060F







 

Career

• 1999-2002 Postdoc, School of Animal and Microbial Sciences, University of Reading
• 2002-2004 Postodc, Department of Leukocyte Biology, Imperial College London
• 2004-2009 Lectuer in Molecular Pharmacology, University of East Anglia, Norwich
• 2009 - Senior Lecturer in Molecular Pharmacology, University of East Anglia, Norwich

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