Biography

PhD studentship opportunity: We currently have one BBSRC-funded PhD studentship available in our group. Please contact Amit Sachdeva (a.sachdeva@uea.ac.uk) directly if you are interested in applying for this position.  Read more - Modulating properties of proteins with non-natural amino acids (SACHDEVA_U17DTP)

Amit Sachdeva is a lecturer in Bio-organic Chemistry at UEA and his research interests are in the area of Chemical Biology and Synthetic Biology. Amit completed his PhD from the University of Illinois at Urbana-Champaign, where he was involved in identification of DNA-based enzymes with potential for biomedical and diagnostic applications. He then moved to Cambridge for postdoctoral work at the MRC Laboratory of Molecular Biology. Here, he was involved in developing methods to enable synthesis of proteins containing multiple non-natural amino acids in live cells.

At the University of East Anglia, Amit’s research group is developing methods to genetically encode new unnatural amino acids that would provide access to several medically important proteins. His research group is also focusing its efforts on modulating properties of proteins to develop novel therapeutics and medical diagnosis tools.

Selected publications

D.T. Rogerson, A. Sachdeva, K. Wang, T. Haq, A. Kazlauskaite, S.M. Hancock, N. Huguenin-Dezot, M.M.K. Muqit, A.M. Fry, R. Bayliss and and J.W. Chin.
Efficient genetic encoding of phosphoserine and its non-hydrolyzable analog.
Nature Chemical Biology, online, 2015, 11, 496-503.

A. Sachdeva, K. Wang, T.S. Elliott and and J.W. Chin.
Concerted, rapid, quantitative and site-specific dual labeling of protein.
Journal of the American Chemical Society (JACS), 2014, 136, 7785-7788.

K. Wang*, A. Sachdeva*, D.J. Cox, N.W. Wilf, K. Lang, S. Wallace R.A. Mehl and J.W. Chin.
Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double labelling and FRET.
Nature Chemistry, 2014, 6, 393-403. (*=Co-first authors)

T.S. Elliott, F.M. Townsley, A. Bianco, R.J. Ernst, A. Sachdeva, S.J. Elsässer, L. Davis, K. Lang, R. Pisa, S. Greiss, Kathryn S. Lilley and J.W. Chin.
Proteome Labeling and Protein Identification in Specific Tissues and at Specific Development Stages in an Animal.
Nature Biotechnology, 2014, 32, 465-472.

S.M. Walsh, A. Sachdeva and S.K. Silverman.
DNA catalysts with tyrosine kinase activity.
Journal of the American Chemical Society (JACS), 2013, 135, 14928-14931.

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