Biography

We are always looking for candidates to join our group for PhD or Postdoctoral work. Please contact Amit Sachdeva (a.sachdeva@uea.ac.uk) directly to express your interest.

PhD studentship opportunity: We currently have one fully funded PhD studentship available in our group. If you are interested in this position, please read more- Lighting up biotherapeutics.

Amit Sachdeva is the Director of Postgraduate Research and lecturer in Bio-organic Chemistry at UEA. His research interests are in the area of Chemical Biology and Synthetic Biology. Amit completed his PhD from the University of Illinois at Urbana-Champaign, where he was involved in identification of DNA-based enzymes with potential for biomedical and diagnostic applications. He then moved to Cambridge for postdoctoral work at the MRC Laboratory of Molecular Biology. Here, he was involved in developing methods to enable synthesis of proteins containing multiple non-natural amino acids in live cells.

At the University of East Anglia, Amit’s research group is interested in developing novel therapeutics and diagnostics. His group has recently developed light-activated antibodies. These antibodies bind to cell surface receptors on live cancer cells only upon irradiation with light of a specific wavelength. His research group is also focusing its efforts on developing methods to genetically encode new unnatural amino acids that would provide access to several medically important proteins.

 

Selected publications

Z. Cheng, E. Kuru, A. Sachdeva & M. Vendrell (2020)
Fluorescent amino acids as versatile building blocks for chemical biology.
Nature Reviews Chemistry, 4, 275.

T. Bridge, S.A. Shaikh, P. Thomas, J. Botta, P.J. McCormick & A. Sachdeva (2019)
Site‐Specific Encoding of Photoactivity in Antibodies Enables Light‐Mediated Antibody–Antigen Binding on Live Cells.
Angewandte Chemie Int. Ed., 58,17986.

D.T. Rogerson, A. Sachdeva, K. Wang, T. Haq, A. Kazlauskaite, S.M. Hancock, N. Huguenin-Dezot, M.M.K. Muqit, A.M. Fry, R. Bayliss and and J.W. Chin.
Efficient genetic encoding of phosphoserine and its non-hydrolyzable analog.
Nature Chemical Biology, online, 2015, 11, 496-503.

A. Sachdeva, K. Wang, T.S. Elliott and and J.W. Chin.
Concerted, rapid, quantitative and site-specific dual labeling of protein.
Journal of the American Chemical Society (JACS), 2014, 136, 7785-7788.

K. Wang*, A. Sachdeva*, D.J. Cox, N.W. Wilf, K. Lang, S. Wallace R.A. Mehl and J.W. Chin.
Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double labelling and FRET.
Nature Chemistry, 2014, 6, 393-403. (*=Co-first authors)

T.S. Elliott, F.M. Townsley, A. Bianco, R.J. Ernst, A. Sachdeva, S.J. Elsässer, L. Davis, K. Lang, R. Pisa, S. Greiss, Kathryn S. Lilley and J.W. Chin.
Proteome Labeling and Protein Identification in Specific Tissues and at Specific Development Stages in an Animal.
Nature Biotechnology, 2014, 32, 465-472.

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